Electron spin resonance study on free radicals in cyclic olefin copolymers irradiated by gamma rays at cryogenic and room temperatures

被引：6

作者：

Zhang, Fan ^{[1
,2
,3
]}

Ji, Zhenyan ^{[1
,2
]}

Zhang, Qiang ^{[1
,2
]}

Shen, Rongfang ^{[1
,2
]}

Xing, Zhe ^{[1
,2
]}

Wu, Guozhong ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

来源：

RADIATION PHYSICS AND CHEMISTRY | 2023年 / 202卷

基金：

中国国家自然科学基金;

关键词：

Cyclic olefin copolymer; Radiation sterilization; Free radical; Reaction mechanism; POLYPROPYLENE; ETHYLENE; PP; STABILITY; KINETICS; BLENDS;

D O I：

10.1016/j.radphyschem.2022.110505

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cyclic olefin copolymers (COCs) are amorphous thermoplastic polymers that require radiation sterilizations when used in prefilled syringes and drug packaging. In the radiation sterilization process, COCs are ionized, and thus, they produce free radicals, which lead to free radical reactions that affect their performance and biosafety. In this study, species of free radicals generated in COCs by gamma-ray irradiation and their decay behaviors under different conditions were investigated using electron spin resonance spectroscopy. Results indicated that many alkyl radicals were produced by the irradiation of COCs in liquid nitrogen, which were transformed to peroxy free radicals upon exposure to air. It was confirmed that free radicals centered on secondary and tertiary carbons were predominant after being irradiated at room temperature by an isotropic simulation, and their concentrations depended on the absorbed dose. After 576 h of storage at room temperature, free radicals were nearly annihilated, or almost decayed, near the glass transition temperature. In addition, this study proposes a free radical reaction mechanism for COCs under different post-processing conditions.

引用

页数：8

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