Microextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography-Tandem Mass Spectrometry

被引：6

作者：

Simao, A. Y. ^{[1
,2
]}

Oliveira, P. ^{[1
,2
]}

Rosendo, L. M. ^{[1
,2
]}

Rosado, T. ^{[1
,2
]}

Andraus, M. ^{[3
]}

Barroso, M. ^{[4
]}

Gallardo, E. ^{[1
,2
]}

机构：

[1] Univ Beira Interior CICS UBI, Ctr Invest Ciencias Saude, Fac Ciencias Saude, P-6200506 Covilha, Portugal

[2] Univ Beira Interior, Lab Farmaco Toxicol UBIMed, P-6200000 Covilha, Portugal

[3] Chromatox Dasa Lab Ltda, BR-01259000 Sao Paulo, SP, Brazil

[4] Inst Nacl Med Legal & Ciencias Forenses Delegacao, Serv Quim & Toxicol Forenses, P-1169201 Lisbon, Portugal

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2023年 / 47卷 / 03期

关键词：

SOLID-PHASE MICROEXTRACTION; MICROPULVERIZED EXTRACTION; PSYCHOACTIVE SUBSTANCES; SCREENING-PROCEDURE; URINE SAMPLES; HUMAN PLASMA; GC-MS; DRUGS; METABOLITES; LIQUID;

D O I：

10.1093/jat/bkac075

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of new psychoactive substances has been increasing and constitutes a social and public health problem, and hence, toxicological analysis has become of utmost importance for the detection of such substances. In this article, we present the development and full validation of a simple, user and environmentally friendly, cheap and suitable method for the determination of ketamine and its main metabolite norketamine in hair samples. The procedure included using a miniaturized procedure-microextraction by packed sorbent with mixed-mode sorbent-for sample clean-up. Organic solvents use was minimal, and it was possible to obtain a linear method (0.05-10 ng/mg for both analytes). The extraction efficiency ranged from 32 to 61%, which did not impair sensitivity. The method proved to be selective, precise, accurate and suitable for routine analysis for the determination of said compounds in 50-mg hair samples.

引用

页码：227 / 235

页数：9

共 59 条

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