How caffeic acid and its derivatives combat diabetes and its complications: A systematic review

被引：23

作者：

Akhlaghipour, Iman ^{[1
]}

Shad, Arya Nasimi ^{[1
]}

Askari, Vahid Reza ^{[2
,3
]}

Maharati, Amirhosein ^{[1
]}

Rahimi, Vafa Baradaran ^{[4
,5
]}

机构：

[1] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran

[5] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Azadi Sq Vakil Abad Highway, Mashhad 9177948564, Iran

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 110卷

关键词：

Caffeic acid; Caffeic acid phenyl ester; Type; 2; diabetes; Insulin; Inflammation; Oxidative stress; PHENETHYL ESTER CAPE; LOWER PLASMA-GLUCOSE; OXIDATIVE STRESS; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; CHLOROGENIC ACIDS; ENDOTHELIAL-CELLS; CINNAMIC ACID; IN-VITRO; INSULIN;

D O I：

10.1016/j.jff.2023.105862

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Caffeic acid (CA) and its derivatives, caffeic acid phenyl ethyl amide (CAPA) and caffeic acid phenyl ester (CAPE), were shown to have anti-oxidant, anti-inflammatory, and anti-diabetic effects. Therefore, in this systematic review, a literature search was conducted from inception until June 2023 on major electronic da-tabases (ISI Web of Science, MEDLINE/PubMed, Scopus, Cochrane Library, and Google Scholar) to find studies evaluating the impacts of CA and its common derivatives on diabetes and its complications in different cellular, animal, and clinical studies. CA and its derivatives therapy mitigated levels of blood glucose, oxidative stress markers, and inflammatory cytokines while increasing levels of anti-oxidative markers in different cellular and animal models of diabetes. Furthermore, they remarkably propagated insulin secretion and ameliorated insulin resistance. CA and its derivatives also revealed protective effects against diabetes complications, such as diabetic -induced hepatic damage, cardiomyopathy, endothelial dysfunction, retinopathy, cognitive deficit, nephropathy, and neuropathy.

引用

页数：16

共 94 条

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