Taurine Improves Sperm Mitochondrial Indices, Blunts Oxidative Stress Parameters, and Enhances Steroidogenesis and Kinematics of Sperm in Lead-Exposed Mice

被引:12
作者
Ommati, Mohammad Mehdi [1 ,2 ,3 ]
Sabouri, Samira [1 ]
Retana-Marquez, Socorro [4 ]
Nategh Ahmadi, Hassan [1 ,5 ]
Arjmand, Abdollah [6 ]
Alidaee, Sepideh [3 ]
Mazloomi, Sahra [3 ]
Akhlagh, Alireza [3 ]
Abdoli, Narges [7 ]
Niknahad, Hossein [3 ]
Jamshidzadeh, Akram [3 ]
Ma, Yanqin [2 ]
Azarpira, Negar [8 ]
Asefi, Yaser [9 ]
Heidari, Reza [3 ]
机构
[1] Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China
[2] Shanxi Agr Univ, Coll Life Sci, Taigu 030801, Shanxi, Peoples R China
[3] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
[4] Autonomous Metropolitan Univ Iztapalapa, Dept Biol Reprod, Mexico City, Mexico
[5] Shiraz Univ, Coll Anim Sci & Vet Med, Shiraz, Iran
[6] Shahid Beheshti Univ Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Tehran, Iran
[7] Minist Hlth, Iran Food & Drug Adm, Tehran, Iran
[8] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran
[9] Islamic Azad Univ, Dept Genet, Ahar Branch, Ahar, Iran
关键词
Heavy metals; Mitochondrial impairment; Oxidative stress; Reproductive toxicity; Spermatozoa; MALE REPRODUCTIVE TOXICITY; INDUCED RENAL INJURY; LIVER-MITOCHONDRIA; PROTECTIVE ROLE; ENVIRONMENTAL EXPOSURE; ORGANOSULFUR COMPOUNDS; MOLECULAR-MECHANISMS; LIPID-PEROXIDATION; N-ACETYLCYSTEINE; HEPATIC-INJURY;
D O I
10.1007/s43032-022-01140-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Lead (Pb) is a highly toxic heavy metal. Pb exposure could adversely affect many organs, including the male reproductive system. Oxidative stress and mitochondrial impairment play a fundamental role in the pathogenesis of Pb-induced male reproductive system injury. Taurine (TAU) is abundantly found in mammalian bodies. The positive effects of TAU on oxidative stress biomarkers and mitochondrial function have been reported. The current study evaluated the effects of TAU on Pb-induced reproductive toxicity. Mice received Pb (20 mg/kg/day; gavage, 35 consecutive days). Then, sperm indices (quality and quantity) together with sperm kinetics, sperm mitochondrial parameters, testicular and sperm oxidative stress biomarkers, testis and plasma testosterone levels, and the expression of genes involved in the steroidogenesis process have been evaluated. Pb caused significant histopathological alterations and oxidative stress in male mice's reproductive system and sperm. Moreover, significant mitochondrial function impairment was evident in sperm isolated from Pb-treated mice. Pb exposure also suppressed the expression of StAR, 17 beta-HSD, CYP11A, and 3 beta-HSD genes in the male gonad. It was found that TAU (500 and 1000 mg/kg) significantly improved oxidative stress biomarkers in both male gonads and gametes of Pb-treated mice. TAU also significantly restored sperm mitochondrial function and kinetics. The expression of genes involved in steroidogenesis was also higher in TAU-treated animals. These data suggest TAU as an effective agent against Pb-induced reproductive toxicity. The effects of TAU on oxidative stress markers, mitochondrial function, and the steroidogenesis process seem to play a fundamental role in its protective properties. Further studies are warranted to detect the precise protective effects of this amino acid in the reproductive system.
引用
收藏
页码:1891 / 1910
页数:20
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