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Low-dose esketamine with sufentanil for postcesarean analgesia in women with gestational diabetes mellitus: a prospective, randomized, double-blind study
被引:6
作者:
Han, Tao
[1
]
Chen, Qin
[1
]
Huang, Jie
[1
]
Zhang, Jie
[1
]
Li, Aiyuan
[1
]
Xu, Wei
[1
]
Peng, Zheming
[1
]
Li, Zhen
[1
]
Chen, Liang
[1
]
机构:
[1] Hunan Prov Maternal & Child Hlth Care Hosp, Dept Anesthesiol, Changsha, Peoples R China
来源:
FRONTIERS IN ENDOCRINOLOGY
|
2023年
/
14卷
关键词:
gestational diabetes;
cesarean delivery;
intravenous patient-controlled analgesia;
esketamine;
prospective study;
POSTOPERATIVE PAIN;
DELIVERY ANALGESIA;
S-KETAMINE;
BENEFITS;
SURGERY;
D O I:
10.3389/fendo.2023.1202734
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background: Pregnant women with gestational diabetes mellitus (GDM) require more analgesics after cesarean delivery than those who do not have GDM. Uncontrolled pain following cesarean delivery is a major problem in women with GDM. We investigate the efficacy of low-dose esketamine combined with sufentanil intravenous patient- controlled analgesia (PCA)for postcesarean analgesia in women with GDM. Methods: One hundred forty pregnant women with GDM were enrolled participate in this randomized controlled trial and were randomized into two groups ( 70 in each group). The esketamine ( S) group was given esketamine +sufentanil + ondansetron, and the control (C) group was given sufentanil +ondansetron. The primary outcome is sufentanil consumption at 24 hours postoperatively, the secondary outcomes are sufentanil consumption at 6 hours postoperatively, pain scores at 6, 24 and 48 hours postoperatively. Results: Compared with group C, group S had significantly lower sufentanil consumption at 6 and 24 hours postoperatively (P= 0.049 and P<0.001), significantly lower activities VAS(pain during activities)scores at 6 hours postoperatively, rest and activities VAS (pain at rest and pain during activities) scores at 24 hours postoperatively, and activities VAS scores at 48 hours postoperatively( P=0.022, P =0.002, P=0.001 and P=0.007). Compared to group C, the time to bowel function return was significantly shorter in group S. There was no significant difference in rest VAS (pain at rest) scores at 6 and 48 hours postoperatively (P>0.05). The time to first lactation was not significantly different between the two groups (P>0.05). There was no significant difference in neonatal neurobehavioral scores between the two groups (P>0.05). Conclusion: Compared to sufentanil PCA, adding low dose of esketamine significantly reduced the consumption of sufentanil while providing equally effective post cesarean analgesia in the patients with gestational diabetes.
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页数:8
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