The role of long noncoding RNAs in malaria parasites

被引:8
作者
Thompson, Trevor A. [1 ]
Chahine, Zeinab [1 ]
Le Roch, Karine G. [1 ]
机构
[1] Univ Calif Riverside, Dept Mol Cell & Syst Biol, Riverside, CA 92521 USA
基金
美国国家卫生研究院;
关键词
MUTUALLY EXCLUSIVE EXPRESSION; INTRAERYTHROCYTIC DEVELOPMENTAL CYCLE; FALCIPARUM-VAR GENES; ANTISENSE TRANSCRIPTS; ANTIGENIC VARIATION; EPIGENETIC MEMORY; G-QUADRUPLEXES; GENOME; REGIONS; CHROMATIN;
D O I
10.1016/j.pt.2023.03.016
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The human malaria parasites, including Plasmodium falciparum, persist as a major cause of global morbidity and mortality. The recent stalling of progress toward malaria elimination substantiates a need for novel interventions. Controlled gene expression is central to the parasite's numerous life cycle transformations and adaptation. With few specific transcription factors (TFs) identified, crucial roles for chromatin states and epigenetics in parasite transcription have become evident. Although many chromatin-modifying enzymes are known, less is known about which factors mediate their impacts on transcriptional variation. Like those of higher eukaryotes, long noncoding RNAs (lncRNAs) have recently been shown to have integral roles in parasite gene regulation. This review aims to summarize recent developments and key findings on the role of lncRNAs in P. falciparum.
引用
收藏
页码:517 / 531
页数:15
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