Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects

被引:53
作者
Li, Xiandeng [1 ,2 ]
Zhang, Ying [1 ]
Xing, Xiaodong [1 ,2 ]
Li, Mi [1 ]
Liu, Yan [1 ]
Xu, Ajing [1 ]
Zhang, Jian [1 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Clin Pharm, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China
[2] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China
关键词
Podocyte injury; Diabetic nephropathy; Pharmacotherapy; Proteinuria; LONG NONCODING RNA; KIDNEY-DISEASE; MITOCHONDRIAL BIOGENESIS; OXIDATIVE STRESS; APOPTOSIS; AUTOPHAGY; PROTECTS; DIFFERENTIATION; HYPERGLYCEMIA; ACCUMULATION;
D O I
10.1016/j.biopha.2023.115670
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it has emerged as a major contributor to endstage renal disease. The glomerular filtration barrier, composed of podocytes, endothelial cells, and the glomerular basement membrane, plays a vital role in maintaining renal function. Disruptions in podocyte function, including hypertrophy, shedding, reduced density, and apoptosis, can impair the integrity of the glomerular filtration barrier, resulting in elevated proteinuria, abnormal glomerular filtration rate, and increased creatinine levels. Hence, recent research has increasingly focused on the role of podocyte injury in DN, with a growing emphasis on exploring therapeutic interventions targeting podocyte injury. Studies have revealed that factors such as lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, and impaired autophagy can contribute to podocyte injury. This review aims to summarize the underlying mechanisms of podocyte injury in DN and provide an overview of the current research status regarding experimental drugs targeting podocyte injury in DN. The findings presented herein may offer potential therapeutic targets and strategies for the management of DN associated with podocyte injury.
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页数:16
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