Innate (learned) memory

被引：16
作者：
Al, Burcu [1 ]
Suen, Tsz K. [1 ]
Placek, Katarzyna [1 ]
Netea, Mihai G. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Bonn, Life & Med Sci Inst, Dept Mol Immunol & Cell Biol, Bonn, Germany
[2] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, Nijmegen, Netherlands
[4] Univ Med Ctr Nijmegen UMCN, Geert Grootepl Zuid 8, NL-6525 GA Nijmegen, Netherlands
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 152卷 / 03期
关键词：
Trained immunity; immune memory; metabolism; epige-netics; cellular signaling; HEMATOPOIETIC STEM-CELLS; INDUCED TRAINED IMMUNITY; CANDIDA-ALBICANS; T-CELLS; NONSPECIFIC PROTECTION; IMMUNOLOGICAL MEMORY; CYTOKINE PRODUCTION; EPITHELIAL-CELLS; TISSUE-REPAIR; LOW-VIRULENCE;
D O I：
10.1016/j.jaci.2023.06.014
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
With the growing body of evidence, it is now clear that not only adaptive immune cells but also innate immune cells can mount a more rapid and potent nonspecific immune response to subsequent exposures. This process is known as trained immunity or innate (learned) immune memory. This review discusses the different immune and nonimmune cell types of the central and peripheral immune systems that can develop trained immunity. This review highlights the intracellular signaling and metabolic and epigenetic mechanisms underlying the formation of innate immune memory. Finally, this review explores the health implications together with the potential therapeutic interventions harnessing trained immunity. (J Allergy Clin Immunol 2023;152:551-66.)
引用
收藏
页码：551 / 566
页数：16
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