Candida parapsilosis sensu stricto Antifungal Resistance Mechanisms and Associated Epidemiology

被引：11
作者：
Franconi, Iacopo [1 ]
Rizzato, Cosmeri [1 ]
Poma, Noemi [2 ]
Tavanti, Arianna [2 ]
Lupetti, Antonella [1 ]
机构：
[1] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Via San Zeno 37, I-56123 Pisa, Italy
[2] Univ Pisa, Dept Biol, Via San Zeno 37, I-56127 Pisa, Italy
来源：
JOURNAL OF FUNGI | 2023年 / 9卷 / 08期
关键词：
Candida parapsilosis; antifungal resistance; antifungal tolerance; heteroresistance; epidemiology of antifungal resistance; antifungal susceptibility tests; ERGOSTEROL BIOSYNTHETIC-PATHWAY; CELL-WALL CHITIN; DRUG-RESISTANCE; AMPHOTERICIN-B; MOLECULAR-MECHANISMS; AZOLE RESISTANCE; FLUCONAZOLE RESISTANCE; ECHINOCANDIN RESISTANCE; REDUCED SUSCEPTIBILITY; ALBICANS;
D O I：
10.3390/jof9080798
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has become a matter of great concern in public health. In recent years rates of non-albicans species have risen dramatically. Candida parapsilosis is now reported to be the second most frequent species causing candidemia in several countries in Europe, Latin America, South Africa and Asia. Rates of acquired azole resistance are reaching a worrisome threshold from multiple reports as in vitro susceptibility testing is now starting also to explore tolerance and heteroresistance to antifungal compounds. With this review, the authors seek to evaluate known antifungal resistance mechanisms and their worldwide distribution in Candida species infections with a specific focus on C. parapsilosis.
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页数：23
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