Short-Chain Fatty Acids as Bacterial Enterocytes and Therapeutic Target in Diabetes Mellitus Type 2

被引:3
作者
Neag, Maria-Adriana [1 ]
Craciun, Anca-Elena [2 ]
Inceu, Andreea-Ioana [1 ]
Burlacu, Diana-Elena [3 ]
Craciun, Cristian-Ioan [1 ]
Buzoianu, Anca-Dana [1 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca 400337, Romania
[2] Iuliu Hatieganu Univ Med, Dept Diabet & Nutr Dis, Pharm, Cluj Napoca 400006, Romania
[3] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Cluj Napoca 400012, Romania
关键词
enteric nervous system; short-chain fatty acids; diabetes mellitus; gut microbiota; glucagon-like peptide 1; GLUCAGON-LIKE PEPTIDE-1; ENTERIC NERVOUS-SYSTEM; TOLL-LIKE RECEPTORS; GUT MICROBIOTA; DOUBLE-BLIND; BRAIN AXIS; PROTEIN; CELLS; NEUROGENESIS; HOMEOSTASIS;
D O I
10.3390/biomedicines11010072
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diabetes mellitus is a disease with multiple gastrointestinal symptoms (diarrhea or constipation, abdominal pain, bloating) whose pathogenesis is multifactorial. The most important of these factors is the enteric nervous system, also known as the "second brain"; a part of the peripheral nervous system capable of functioning independently of the central nervous system. Modulation of the enteric nervous system can be done by short-chain fatty acids, which are bacterial metabolites of the intestinal microbiota. In addition, these acids provide multiple benefits in diabetes, particularly by stimulating glucagon-like peptide 1 and insulin secretion. However, it is not clear what type of nutraceuticals (probiotics, prebiotics, and alimentary supplements) can be used to increase the amount of short-chain fatty acids and achieve the beneficial effects in diabetes. Thus, even if several studies demonstrate that the gut microbiota modulates the activity of the ENS, and thus, may have a positive effect in diabetes, further studies are needed to underline this effect. This review outlines the most recent data regarding the involvement of SCFAs as a disease modifying agent in diabetes mellitus type 2. For an in-depth understanding of the modulation of gut dysbiosis with SCFAs in diabetes, we provide an overview of the interplay between gut microbiota and ENS.
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页数:18
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