IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population

被引：3

作者：

Palazuelos, Carlos Ernesto Mora ^{[1
]}

Medina, Elsa Maribel Aguilar ^{[1
]}

Felix, Mariana Melisa Avendano ^{[1
]}

Payan, Rosalio Ramos ^{[1
]}

Cortes, Mercedes Bermudez ^{[2
]}

Avila, Leticia Lara ^{[1
]}

Salazar, Adrian Herrera ^{[1
]}

Llanes, Joel Murillo ^{[3
]}

Sanchez-Schmitz, Guzman ^{[4
]}

Quintana, Jose Geovanni Romero ^{[1
,5
]}

机构：

[1] Univ Autonoma Sinaloa, Blvd Miguel Tamayo Espinosa Monteros S-N,Torre Rec, Culiacan, Mexico

[2] Autonomous Univ Chihuahua, Chihuahua, Mexico

[3] Hosp Mujer, Culiacan, Mexico

[4] Harvard Med Sch, Boston, MA USA

[5] Univ Autonoma Sinaloa, Blvd Miguel Tamayo Espinosa Monteros S-N, Culiacan 80050, Mexico

来源：

GINEKOLOGIA POLSKA | 2024年 / 95卷 / 02期

关键词：

IL-6; IL-10; TNF-alpha; preeclampsia; SNP; NECROSIS-FACTOR-ALPHA; INTERLEUKIN-10; GENE; ASSOCIATION; WOMEN; INFLAMMATION; INFECTION; RECEPTOR; RISK;

D O I：

10.5603/gpl.94272

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-alpha (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women. Material and methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-alpha and IL-10 was performed using TaqMan SNP Genotyping. Results: Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-alpha and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-alpha (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium. Conclusions: According to the findings, the IL-6, TNF-alpha and IL-10 SNPs are not exponents of susceptibility to developing PE.

引用

页码：108 / 113

页数：6

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