Vitamin B3 Supplementation for Optic Neuropathies: A Comprehensive Review

被引：1

作者：

Almeida, Julio ^{[1
,6
]}

Costa, Tomas R. ^{[1
]}

Vivas, Maria ^{[1
]}

Monteiro, Catarina ^{[1
]}

Vaz, Fernando T. ^{[1
]}

Ferreira, Quirina ^{[2
]}

Prieto, Isabel ^{[1
]}

Pinto, Luis A. ^{[3
,4
]}

Ferreira, Joana T. ^{[3
,4
,5
]}

机构：

[1] Prof Doutor Fernando Fonseca Hosp, Ophthalmol Dept, EPE, Amadora, Portugal

[2] iNOVA4Hlth New Univ Lisbon, Lisbon, Portugal

[3] CHU Lisboa Norte, Ophthalmol Dept, EPE, Lisbon, Portugal

[4] Univ Lisbon, Fac Med, Visual Sci Study Ctr, Lisbon, Portugal

[5] Hosp CUF Descobertas, Ophthalmol Dept, Lisbon, Portugal

[6] Prof Doutor Fernando Fonseca Hosp, Ophthalmol Dept, EPE, IC19 276, P-2720276 Amadora, Portugal

来源：

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | 2024年 / 40卷 / 02期

关键词：

vitamin B-3; nicotinamide; optic neuropathy; glaucoma; neuroregeneration; GLAUCOMA;

D O I：

10.1089/jop.2023.0125

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Optic neuropathies, such as glaucoma, are some of the leading causes of irreversible blindness worldwide. There has been a lot of research for potential therapies that could attenuate and even reduce the impact of the pathological pathways that lead to the loss of retinal ganglion cells (RGCs). In recent years, vitamin B-3 (nicotinamide) has gained some interest as a viable option for these neurodegenerative diseases due to its fundamental role in enhancing the mitochondria metabolism of the RGCs. This review focuses on elucidating the impact of vitamin B-3 on retinal cells, especially when in a dysfunctional state like what happens in optic neuropathies, especially glaucoma. This review also summarizes the existing and future research on the clinical effects of vitamin B-3 in these optic neuropathies, and determines appropriate recommendations regarding its dosing, efficacy, and eventual side effects.

引用

页码：111 / 116

页数：6

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