Gold-catalyzed alkenylation and arylation of phosphorothioates

被引：22
|
作者：
Mishra, Sampoorna [1 ]
Patil, Nitin T. [1 ]
机构：
[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal Bypass Rd, Bhopal 462066, India
来源：
CHEMICAL SCIENCE | 2023年 / 14卷 / 45期
关键词：
S-ARYL; PROMOTED SYNTHESIS; H-PHOSPHONATES; GENERAL-METHOD; ACETYLCHOLINESTERASE; THIOPHOSPHATES; INHIBITION; ACIDS;
D O I：
10.1039/d3sc04888h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides. Mechanistic studies revealed a crucial role of the in situ generated Ag-sulfur complex, which undergoes a facile transmetalation with the Au(iii) intermediate, thereby leading to the successful realization of the present reaction. Moreover, for the first time, the alkenylation of phosphoroselenoates under gold redox catalysis has been presented. Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides.
引用
收藏
页码：13134 / 13139
页数：6
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