Physiological effects of ivabradine in heart failure and beyond

被引：3
作者：
Iness, Audra N. [1 ]
Shah, Keyur M. [2 ]
Kukreja, Rakesh C. [2 ]
机构：
[1] Baylor Coll Med, Dept Pediat, Houston, TX USA
[2] Virginia Commonwealth Univ, Pauley Heart Ctr, Div Cardiol, Internal Med, Richmond, VA 23284 USA
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2024年 / 479卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Heart failure; Sinoatrial node; Ischemia; Ivabradine; Funny current; CORONARY-ARTERY-DISEASE; CURRENT INHIBITOR IVABRADINE; F-CHANNEL INHIBITOR; RATE REDUCTION; I-F; BRADYCARDIAC AGENT; DOUBLE-BLIND; MYOCARDIAL-ISCHEMIA; PROGNOSTIC VALUE; STABLE ANGINA;
D O I：
10.1007/s11010-023-04862-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ivabradine is a pharmacologic agent that inhibits the funny current responsible for determining heart rate in the sinoatrial node. Ivabradine's clinical potential has been investigated in the context of heart failure since it is associated with reduced myocardial oxygen demand, enhanced diastolic filling, stroke volume, and coronary perfusion time; however, it is yet to demonstrate definitive mortality benefit. Alternative effects of ivabradine include modulation of the renin-angiotensin-aldosterone system, sympathetic activation, and endothelial function. Here, we review key clinical trials informing the clinical use of ivabradine and explore opportunities for leveraging its potential pleiotropic effects in other diseases, including treatment of hyperadrenergic states and mitigating complications of COVID-19 infection.
引用
收藏
页码：2405 / 2414
页数：10
相关论文
共 93 条
  • [11] Heart Failure
    Braunwald, Eugene
    [J]. JACC-HEART FAILURE, 2013, 1 (01) : 1 - 20
  • [12] Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
    Bucchi, A
    Tognati, A
    Milanesi, R
    Baruscotti, M
    DiFrancesco, D
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2006, 572 (02): : 335 - 346
  • [13] Dysautonomia in COVID-19 Patients: A Narrative Review on Clinical Course, Diagnostic and Therapeutic Strategies
    Carmona-Torre, Francisco
    Minguez-Olaondo, Ane
    Lopez-Bravo, Alba
    Tijero, Beatriz
    Grozeva, Vesselina
    Walcker, Michaela
    Azkune-Galparsoro, Harkaitz
    de Munain, Adolfo Lopez
    Alcaide, Ana Belen
    Quiroga, Jorge
    del Pozo, Jose Luis
    Gomez-Esteban, Juan Carlos
    [J]. FRONTIERS IN NEUROLOGY, 2022, 13
  • [14] Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure
    Cavusoglu, Yuksel
    Mert, Ugur
    Nadir, Aydin
    Mutlu, Fezan
    Morrad, Bektas
    Ulus, Taner
    [J]. JOURNAL OF CARDIOVASCULAR MEDICINE, 2015, 16 (09) : 603 - 609
  • [15] Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart
    Ceconi, Claudio
    Cargnoni, Anna
    Francolini, Gloria
    Parinello, Giovanni
    Ferrari, Roberto
    [J]. CARDIOVASCULAR RESEARCH, 2009, 84 (01) : 72 - 82
  • [16] COVID-19: A Multidisciplinary Review
    Chams, Nour
    Chams, Sana
    Badran, Reina
    Shams, Ali
    Araji, Abdallah
    Raad, Mohamad
    Mukhopadhyay, Sanjay
    Stroberg, Edana
    Duval, Eric J.
    Barton, Lisa M.
    Hussein, Inaya Hajj
    [J]. FRONTIERS IN PUBLIC HEALTH, 2020, 8
  • [17] Ivabradine in Cardiovascular Disease Management Revisited: a Review
    Chen, Christopher
    Kaur, Gurleen
    Mehta, Puja K.
    Morrone, Doralisa
    Godoy, Lucas C.
    Bangalore, Sripal
    Sidhu, Mandeep S.
    [J]. CARDIOVASCULAR DRUGS AND THERAPY, 2021, 35 (05) : 1045 - 1056
  • [18] I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice
    Chen, Shao-Liang
    Hu, Zuo-Ying
    Zuo, Guang-Feng
    Li, Ming-Hui
    Li, Bin
    [J]. BMC CARDIOVASCULAR DISORDERS, 2014, 14
  • [19] Combination of calcium channel blockers and beta-blockers for patients with exercise-induced angina pectoris:: Beneficial effect of calcium channel blockers largely determined by their effect on heart rate
    Cleophas, TJ
    van der Sluijs, J
    van der Vring, JA
    Daniëls, MC
    Holwerda, KJ
    Withagen, AJ
    Schelling, A
    Hendriks, MG
    Zwinderman, AH
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 39 (07) : 738 - 746
  • [20] Differential effects of heart rate reduction and β-blockade on left ventricular relaxation during exercise
    Colin, P
    Ghaleh, B
    Hittinger, L
    Monnet, X
    Slama, M
    Giudicelli, JF
    Berdeaux, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (02): : H672 - H679
12345678910