Whole-genome methylation analysis of aging human tissues identifies age-related changes in developmental and neurological pathways

被引：2
作者：
Tharakan, Ravi [1 ,2 ]
Ubaida-Mohien, Ceereena [1 ]
Dunn, Christopher [3 ]
Kaileh, Mary [3 ]
Tryggvadottir, Rakel [4 ]
Zukley, Linda [1 ]
Chia, Chee W. W. [1 ]
Sen, Ranjan [3 ]
Ferrucci, Luigi [1 ,5 ]
机构：
[1] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA
[2] NIA, Lab Genet & Genom, NIH, Baltimore, MD 21224 USA
[3] NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA
[4] Johns Hopkins Univ, Ctr Epigenet, Sch Med, Baltimore, MD USA
[5] NIA, Translat Gerontol Branch, Intramural Res Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA
来源：
AGING CELL | 2023年 / 22卷 / 07期
关键词：
aging; epigenome; monocytes; skeletal muscle; DNA METHYLATION; STEM-CELLS; HYPERMETHYLATION; MACROPHAGES; MONOCYTES; PROFILES;
D O I：
10.1111/acel.13847
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Age-associated changes in the DNA methylation state can be used to assess the pace of aging. However, it is not understood what mechanisms drive these changes and whether these changes affect the development of aging phenotypes and the aging process in general. This study was aimed at gaining a more comprehensive understanding of aging-related methylation changes across the whole genome, and relating these changes to biological functions. It has been shown that skeletal muscle and blood monocytes undergo typical changes with aging. Using whole-genome bisulfite sequencing, we sought to characterize the genome-wide changes in methylation of DNA derived from both skeletal muscle and blood monocytes, and link these changes to specific genes and pathways through enrichment analysis. We found that methylation changes occur with aging at the locations enriched for developmental and neuronal pathways regulated in these two peripheral tissues. These results contribute to our understanding of changes in epigenome in human aging.
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页数：12
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