Stability of nonsteroidal anti-inflammatory drugs in urine and solution: effects of degradation on analytical assessment

被引：1

作者：

Goktas, Eylem Funda ^{[1
]}

Kabil, Erol ^{[1
]}

机构：

[1] Istanbul Pendik Vet Control Inst, Dept Pharmacol, Doping Control Lab, TR-34890 Istanbul, Turkiye

来源：

BIOANALYSIS | 2023年 / 15卷 / 07期

关键词：

GC-MS; nonsteroidal anti-inflammatory drugs; stability; toxicology; urine; validation; LONG-TERM STABILITY; LIQUID-CHROMATOGRAPHY; DOPING AGENTS; BLOOD; QUANTIFICATION; PHENYLBUTAZONE; TESTOSTERONE; CATHINONES;

D O I：

10.4155/bio-2023-0029

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aims: Knowledge of optimal storage conditions of drugs is crucial for properly interpreting analytical assessments. Materials & methods: The current study aimed to investigate the stability of some nonsteroidal anti-inflammatory drugs using a validated method by gas chromatography (GC)-MS. For this propose, long-term, short-term and solution stability were investigated. Results: The analytes remained stable in the sample, similar to the working solution. The most affected substance over time in both matrix and working solution was phenylbutazone. The freeze-thaw cycle affected flunixin and carprofen, but diclofenac and vedaprofen changed only in the third cycle. In short-term stability, high-temperature conditions changed carprofen. Conclusion: The present study is a comprehensive assay for nonsteroidal anti-inflammatory drug stability and can be used as a reference for results assessment.

引用

页码：407 / 419

页数：13

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