The Expression of Programmed Death-Ligand 1 on Immune Cells Is Related to a Better Prognosis in Biliary Tract Cancer

被引：1

作者：

Kwon, Sung Chan ^{[1
]}

Bang, Seungmin ^{[1
]}

Park, Young Nyun ^{[2
]}

Park, Ji Hoon ^{[1
]}

Kim, So Jeong ^{[1
]}

Jo, Jung Hyun ^{[1
]}

Chung, Moon Jae ^{[1
]}

Park, Jeong Youp ^{[1
]}

Park, Seung Woo ^{[1
]}

Song, Si Young ^{[1
]}

Park, Eunhyang ^{[2
]}

Lee, Hee Seung ^{[1
]}

机构：

[1] Yonsei Univ, Inst Gastroenterol, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea

来源：

GUT AND LIVER | 2023年 / 17卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Biliary tract neoplasms; Prognosis; Survival; MISMATCH REPAIR DEFICIENCY; PD-L1; EXPRESSION; PEMBROLIZUMAB; INHIBITORS; EFFICACY; TUMORS;

D O I：

10.5009/gnl220206

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Programmed death-ligand 1 (PD-L1) expression in tumor cells is associ-ated with a poor biliary tract cancer (BTC) prognosis; tumor-infiltrating immune cells in the tumor microenvironment are associated with a better prognosis. The effect of PD-L1 expression on immune cells on survival is unclear. We investigated the relationship between PD-L1 expression in immune cells and BTC prognosis.Methods: PD-L1 expression was evaluated using an anti-PD-L1 22C3 mouse monoclonal pri-mary antibody, and its relationships with clinical characteristics and prognosis were analyzed using the Cox proportional hazard model to investigate the prognostic performance of PD-L1 in BTC.Results: Among 144 analyzed cases, patients with positive PD-L1 expression in tumor cells and negative PD-L1 expression in immune cells showed poorer overall survival rates than those exhibiting other expressions (tumor cells: hazard ratio [HR]=1.023, p<0.001; immune cells: HR=0.983, p=0.021). PD-L1 expression in tumor cells was an independent predictor of poor overall survival (HR=1.024, p<0.001). In contrast, PD-L1 expression in immune cells was a pre-dictive marker of good prognosis (HR=0.983, p=0.018).Conclusions: PD-L1 expression in immune cells may be used as an independent factor to eval-uate the prognosis of patients with BTC. (Gut Liver, Published online December 13, 2022)

引用

页码：933 / 941

页数：9

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