Synthesis of γ-Undecalactone via Organophotocatalyzed α-C-H Alkylation of 1-Octanol using Continuous-Flow Photoreactors

被引：1

作者：

Xu, Meichen ^{[1
]}

Yang, Xiao ^{[1
]}

Li, Yiming ^{[2
]}

Miao, Cunqian ^{[2
]}

Ye, Juntao ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China

[2] Shanghai 3S Technol Co Ltd, 525 Yuanjiang Rd, Shanghai 200241, Peoples R China

来源：

TETRAHEDRON LETTERS | 2024年 / 137卷

基金：

中国国家自然科学基金;

关键词：

Lactone; Alkylation; Flow chemistry; Hydrogen atom transfer; Organophotoredox catalysis; PHOTOREDOX CATALYSIS; LIGHT; LACTONES; DERIVATIVES; EFFICIENT;

D O I：

10.1016/j.tetlet.2024.154939

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

gamma-Undecalactone has a powerful peach aroma and is widely used in the field of flavor and pharmaceutical industry. Herein we report an organophotocatalyzed one-pot approach for the synthesis of gamma-undecalactone from 1octanol and methyl acrylate using continuous-flow photoreactors. By using readily available and inexpensive 4CzIPN as the photocatalyst, the alpha-C-H alkylation reaction can be easily scaled up to 3 mol with a catalyst loading of 0.08 %.

引用

页数：4

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