The problem of immune thrombocytopenia refractory to both eltrombopag and romiplostim

被引:1
作者
Al-Samkari, Hanny [1 ,4 ]
Schifferli, Alexandra [2 ]
Gonzalez-Lopez, Tomas J. [3 ]
机构
[1] Harvard Sch Med, Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA USA
[2] Univ Childrens Hosp Basel, Dept Hematol Oncol, Basel, Switzerland
[3] Hosp Univ Burgos, Hematol Dept, Burgos, Spain
[4] Massachusetts Gen Hosp, Div Hematol Oncol, Bartlett Hall,Off 133,55 Fruit St, Boston, MA 02114 USA
关键词
eltrombopag; immune thrombocytopenia; refractory; romiplostim; thrombopoietin receptor agonist;
D O I
10.1111/bjh.19327
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Immune thrombocytopenia refractory to multiple thrombopoietin receptor agonists remains a challenging clinical problem. This commentary discusses and contextualizes the recent report on this entity from Moulis and colleagues, and how to move forward with these patients. Commentary on: Moulis et al. Difficult-to-treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN-France Registry. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19288.
引用
收藏
页码:1143 / 1145
页数:3
相关论文
共 14 条
[1]   Novel therapeutics and future directions for refractory immune thrombocytopenia [J].
Al-Samkari, Hanny ;
Neufeld, Ellis J. .
BRITISH JOURNAL OF HAEMATOLOGY, 2023, 203 (01) :65-78
[2]   Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study [J].
Al-Samkari, Hanny ;
Jiang, Debbie ;
Gernsheimer, Terry ;
Liebman, Howard ;
Lee, Susie ;
Wojdyla, Matthew ;
Vredenburg, Michael ;
Cuker, Adam .
BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 (03) :359-366
[3]  
AlSamkari H., 2023, RES PRACT THROMB HAE, V7
[4]   Refractory immune thrombocytopenia in adults: Towards a new definition [J].
Arnold, Donald M. ;
Clerici, Bianca ;
Ilicheva, Ekaterina ;
Ghanima, Waleed .
BRITISH JOURNAL OF HAEMATOLOGY, 2023, 203 (01) :23-27
[5]   Combining thrombopoietin receptor agonists with immunosuppressive drugs in adult patients with multirefractory immune thrombocytopenia, an update on the French experience [J].
Crickx, Etienne ;
Ebbo, Mikael ;
Riviere, Etienne ;
Souchaud-Debouverie, Odile ;
Terriou, Louis ;
Audia, Sylvain ;
Ruivard, Marc ;
Asli, Bouchra ;
Marolleau, Jean-Pierre ;
Meaux-Ruault, Nadine ;
Gerfaud-Valentin, Mathieu ;
Audeguy, Philippe ;
Hamidou, Mohamed ;
Corm, Selim ;
Delbrel, Xavier ;
Fontan, Jean ;
Lebon, Delphine ;
Mausservey, Christelle ;
Moulis, Guillaume ;
Limal, Nicolas ;
Michel, Marc ;
Godeau, Bertrand ;
Mahevas, Matthieu .
BRITISH JOURNAL OF HAEMATOLOGY, 2023, 202 (04) :883-889
[6]   Successful discontinuation of eltrombopag after complete remission in patients with primary immune thrombocytopenia [J].
Jose Gonzalez-Lopez, Tomas ;
Pascual, Cristina ;
Teresa Alvarez-Roman, Maria ;
Fernandez-Fuertes, Fernando ;
Sanchez-Gonzalez, Blanca ;
Caparros, Isabel ;
Jarque, Isidro ;
Eva Mingot-Castellano, Maria ;
Angel Hernandez-Rivas, Jose ;
Martin-Salces, Monica ;
Solan, Laura ;
Beneit, Paola ;
Jimenez, Reyes ;
Bernat, Silvia ;
Andrade, Marcio M. ;
Cortes, Montserrat ;
Jose Cortti, Maria ;
Perez-Crespo, Susana ;
Gomez-Nunez, Marta ;
Olivera, Pavel E. ;
Perez-Rus, Gloria ;
Martinez-Robles, Violeta ;
Alonso, Rafael ;
Fernandez-Rodriguez, Angeles ;
Carmen Arratibel, Maria ;
Perera, Maria ;
Fernandez-Minano, Carmen ;
Angel Fuertes-Palacio, Miguel ;
Andres Vazquez-Paganini, Juan ;
Gutierrez-Jomarron, Isabel ;
Valcarce, Ines ;
de Cabo, Erik ;
Sainz, Adriana ;
Fisac, Rosa ;
Aguilar, Carlos ;
Paz Martinez-Badas, Maria ;
Jesus Penarrubia, Maria ;
Calbacho, Maria ;
de Cos, Carmen ;
Gonzalez-Silva, Manuel ;
Coria, Erika ;
Alonso, Arancha ;
Casaus, Alberto ;
Luana, Armando ;
Galan, Pilar ;
Fernandez-Canal, Cristina ;
Garcia-Frade, Javier ;
Ramon Gonzalez-Porras, Jose .
AMERICAN JOURNAL OF HEMATOLOGY, 2015, 90 (03) :E40-E43
[7]   Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia [J].
Kuter, David J. ;
Efraim, Merlin ;
Mayer, Jiri ;
Trneny, Marek ;
McDonald, Vickie ;
Bird, Robert ;
Regenbogen, Thomas ;
Garg, Mamta ;
Kaplan, Zane ;
Tzvetkov, Nikolay ;
Choi, Philip Y. ;
Jansen, A. J. Gerard ;
Kostal, Milan ;
Baker, Ross ;
Gumulec, Jaromir ;
Lee, Eun-Ju ;
Cunningham, Ilona ;
Goncalves, Isaac ;
Warner, Margaret ;
Boccia, Ralph ;
Gernsheimer, Terry ;
Ghanima, Waleed ;
Bandman, Olga ;
Burns, Regan ;
Neale, Ann ;
Thomas, Dolca ;
Arora, Puneet ;
Zheng, Beiyao ;
Cooper, Nichola .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (15) :1421-1431
[8]  
Moulis G., 2024, BRIT J HAEMATOL
[9]   A proposal for new definition (s) and management approach to paediatric refractory ITP: Reflections from the Intercontinental ITP Study Group [J].
Neunert, Cindy ;
Heitink-Polle, Katja M. J. ;
Lambert, Michele P. .
BRITISH JOURNAL OF HAEMATOLOGY, 2023, :17-22
[10]   B cells and antibodies in refractory immune thrombocytopenia [J].
Roeser, Anais ;
Lazarus, Alan H. ;
Mahevas, Matthieu .
BRITISH JOURNAL OF HAEMATOLOGY, 2023, 203 (01) :43-53