Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis

被引：0

作者：

Ponzetto, Ester ^{[1
]}

Delhez, Quentin ^{[1
]}

Hoppenbrouwers, Maarten ^{[2
]}

De Schryver, Nicolas ^{[1
]}

Serck, Nicolas ^{[1
]}

Dugernier, Thierry ^{[1
]}

Duray, Marie-Celine ^{[3
]}

Gressens, Benjamin ^{[1
]}

Vinetti, Marco ^{[1
]}

Sips, Gregorius J. ^{[2
,4
]}

van Kampen, Jeroen ^{[2
]}

Geurtsvankessel, Corine H. ^{[2
]}

van Boheemen, Sander ^{[2
]}

机构：

[1] Clin St Pierre, Intens Care Unit, Ave Reine Fabiola 9, B-1340 Ottignies, Belgium

[2] Erasmus MC, Dept Viroscience, Rotterdam, Netherlands

[3] Clin St Pierre, Dept Neurol, Ottignies, Belgium

[4] Publ Hlth Serv Rotterdam Rijnmond, Rotterdam, Netherlands

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2023年 / 109卷 / 06期

关键词：

SIMPLEX ENCEPHALITIS; INFECTION; ENCEPHALOMYELITIS; SIMIAE; MACAQUE;

D O I：

10.4269/ajtmh.23-0253

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.

引用

页码：1277 / 1281

页数：5

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