P2X7 Receptor: an Emerging Target in Alzheimer's Disease

被引：12

作者：

Huang, Qiang ^{[1
,2
]}

Ying, Jun ^{[1
,2
]}

Yu, Wen ^{[1
,2
]}

Dong, Yao ^{[1
,2
]}

Xiong, Hao ^{[1
,2
]}

Zhang, Yiping ^{[1
,2
]}

Liu, Jie ^{[1
,2
]}

Wang, Xifeng ^{[3
]}

Hua, Fuzhou ^{[1
,2
]}

机构：

[1] Nanchang Univ, Dept Anesthesiol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China

[2] Key Lab Anesthesiol Jiangxi Prov, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Affiliated Hosp 1, Dept Anesthesiol, 17 Yongwai Rd, Nanchang 330006, Jiangxi, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2024年 / 61卷 / 05期

关键词：

Alzheimer's disease; Mitochondrial dysfunction; Neuroinflammation; Oxidative stress; PURINERGIC P2X(7) RECEPTOR; AMYLOID PRECURSOR PROTEIN; OXIDATIVE STRESS; TAU PATHOLOGY; MITOCHONDRIAL DYSFUNCTION; MOUSE MODEL; INTRACELLULAR CALCIUM; MICROGLIAL ACTIVATION; SUPEROXIDE-PRODUCTION; NLRP3; INFLAMMASOME;

D O I：

10.1007/s12035-023-03699-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a global health crisis. However, the pathogenesis and etiology of AD are still not fully understood. And there are no valid treatment methods or precise diagnostic tools for AD. There is increasing evidence that P2X7R expression is upregulated in AD and is involved in multiple related pathological processes such as A beta plaques, neurogenic fiber tangles, oxidative stress, and chronic neuroinflammation. This suggests that P2X7R may be a key player in the development of AD. P2X7R is a member of the ligand-gated purinergic receptor (P2X) family. It has received attention in neuroscience due to its role in a wide range of aging and age-related neurological disorders. In this review, we summarize current information on the roles of P2X7R in AD and suggest potential pharmacological interventions to slow down AD progression.

引用

页码：2866 / 2880

页数：15

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