Hepatocellular Carcinoma With Tumor Thrombus Extension Into the Right Atrium of the Heart

被引:2
作者
Mebane, Nova B. [1 ]
Wells, Rosemary E. [2 ]
Bevinal, Manzoor [1 ]
机构
[1] Corpus Christi Med Ctr, Internal Med, Corpus Christi, TX 78412 USA
[2] Texas Coll Osteopath Med, Internal Med, Ft Worth, TX USA
关键词
inferior vena cava tumor thrombus; transarterial chemoembolization (tace); atezolizumab plus bevacizumab; right atrium tumor thrombus; advanced hepatocellular carcinoma; SURVEILLANCE;
D O I
10.7759/cureus.46582
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Most patients present to the hospital with systemic symptoms and typically have a history of liver disease. This case study involves a male in his 60s who presented to our hospital facility with a chief complaint of abdominal pain. He reported no history of liver disease but was diagnosed with HCC stage IVB during this hospitalization. Upon further imaging, a tumor thrombus was found invading the inferior vena cava with an extension into the right atrium. Our primary learning point in this article is to emphasize the importance of prompt surveillance for primary care physicians with patients who are at increased risk for HCC. Additionally, we discuss specific management aimed toward patients diagnosed with a tumor thrombus extending into the right atrium. This management includes dual immunotherapy (atezolizumab and bevacizumab) and transarterial chemotherapy embolization (TACE).
引用
收藏
页数:7
相关论文
共 13 条
[1]   Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma [J].
Finn, Richard S. ;
Qin, Shukui ;
Ikeda, Masafumi ;
Galle, Peter R. ;
Ducreux, Michel ;
Kim, Tae-You ;
Kudo, Masatoshi ;
Breder, Valeriy ;
Merle, Philippe ;
Kaseb, Ahmed O. ;
Li, Daneng ;
Verret, Wendy ;
Xu, Derek-Zhen ;
Hernandez, Sairy ;
Liu, Juan ;
Huang, Chen ;
Mulla, Sohail ;
Wang, Yulei ;
Lim, Ho Yeong ;
Zhu, Andrew X. ;
Cheng, Ann-Lii .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (20) :1894-1905
[2]   Biology and significance of alpha-fetoprotein in hepatocellular carcinoma [J].
Galle, Peter R. ;
Foerster, Friedrich ;
Kudo, Masatoshi ;
Chan, Stephen L. ;
Llovet, Josep M. ;
Qin, Shukui ;
Schelman, William R. ;
Chintharlapalli, Sudhakar ;
Abada, Paolo B. ;
Sherman, Morris ;
Zhu, Andrew X. .
LIVER INTERNATIONAL, 2019, 39 (12) :2214-2229
[3]   Risk Factors for Patients with Stage IVB Hepatocellular Carcinoma and Extension into the Heart: Prognostic and Therapeutic Implications [J].
Jun, Chung Hwan ;
Sim, Da Woon ;
Kim, Sang Ho ;
Hong, Hyoung Ju ;
Chung, Min Woo ;
Cho, Sung Bum ;
Park, Chang Hwan ;
Joo, Young Eun ;
Kim, Hyun Soo ;
Choi, Sung Kyu ;
Rew, Jong Sun .
YONSEI MEDICAL JOURNAL, 2014, 55 (02) :379-386
[4]   Diffuse Infiltrative Hepatocellular Carcinoma: Assessment of Presentation, Treatment, and Outcomes [J].
Kneuertz, Peter J. ;
Demirjian, Aram ;
Firoozmand, Amin ;
Corona-Villalobos, Celia ;
Bhagat, Nikhil ;
Herman, Joseph ;
Cameron, Andrew ;
Gurakar, Ahmet ;
Cosgrove, David ;
Choti, Michael A. ;
Geschwind, Jean-Francois H. ;
Kamel, Ihab R. ;
Pawlik, Timothy M. .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (09) :2897-2907
[5]   Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence [J].
Raoul, Jean-Luc ;
Forner, Alejandro ;
Bolondi, Luigi ;
Cheung, Tan To ;
Kloeckner, Roman ;
de Baere, Thierry .
CANCER TREATMENT REVIEWS, 2019, 72 :28-36
[6]  
Richardson J, 2021, J Cancer Prev Curr Res, V12, P167
[7]   Novel Cellular Therapies for Hepatocellular Carcinoma [J].
Roddy, Harriet ;
Meyer, Tim ;
Roddie, Claire .
CANCERS, 2022, 14 (03)
[8]   Hepatocellular carcinoma surveillance: the often-neglected practice [J].
Sammon, Jennifer ;
Khalili, Korosh .
HEPATOBILIARY SURGERY AND NUTRITION, 2020, 9 (01) :77-79
[9]   Utilization of Hepatocellular Carcinoma Surveillance Among American Patients: A Systematic Review [J].
Singal, Amit G. ;
Yopp, Adam ;
Skinner, Celette S. ;
Packer, Milton ;
Lee, William M. ;
Tiro, Jasmin A. .
JOURNAL OF GENERAL INTERNAL MEDICINE, 2012, 27 (07) :861-867
[10]   Contemporary role of liver biopsy in hepatocellular carcinoma [J].
Sparchez, Zeno ;
Mocan, Tudor .
WORLD JOURNAL OF HEPATOLOGY, 2018, 10 (07) :452-461