Therapeutic Effects of Baicalin on Diseases Related to Gut-Brain Axis Dysfunctions

被引：11
作者：
Hu, Qichao [1 ]
Hou, Shuyu [1 ]
Xiong, Baoyi [2 ,3 ]
Wen, Yueqiang [4 ]
Wang, Jundong [1 ,5 ]
Zeng, Jinhao [2 ,5 ]
Ma, Xiao [1 ]
Wang, Fang [6 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
[2] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu 610072, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Chengdu 610075, Peoples R China
[4] Chengdu Univ Tradit Chinese Med, Sch Basic Med, Chengdu 611137, Peoples R China
[5] Hosp Chengdu Univ Tradit Chinese Med, Dept Gastroenterol, Chengdu 610072, Peoples R China
[6] Peoples Liberat Army Gen Hosp, Med Supplies Ctr PLA Gen, Dept Pharm, Beijing 100039, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 18期
关键词：
baicalin; the gut-brain axis; gut microbiome; Alzheimer's disease; depression; obesity; NLRP3 INFLAMMASOME ACTIVATION; PARKINSONS-DISEASE; SIGNALING PATHWAY; ISCHEMIC-STROKE; SENSORY NEURONS; RATS; MICROBIOTA; MODEL; APOPTOSIS; COLITIS;
D O I：
10.3390/molecules28186501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gut-brain axis is an active area of research. Several representative diseases, including central nervous system disorders (Alzheimer's disease, Parkinson's disease, and depression), metabolic disorders (obesity-related diseases), and intestinal disorders (inflammatory bowel disease and dysbiosis), are associated with the dysfunctional gut-brain axis. Baicalin, a bioactive flavonoid extracted from Scutellaria baicalensis, is reported to exert various pharmacological effects. This narrative review summarizes the molecular mechanisms and potential targets of baicalin in disorders of the gut-brain axis. Baicalin protects the central nervous system through anti-neuroinflammatory and anti-neuronal apoptotic effects, suppresses obesity through anti-inflammatory and antioxidant effects, and alleviates intestinal disorders through regulatory effects on intestinal microorganisms and short-chain fatty acid production. The bioactivities of baicalin are mediated through the gut-brain axis. This review comprehensively summarizes the regulatory role of baicalin in gut-brain axis disorders, laying a foundation for future research, although further confirmatory basic research is required.
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页数：20
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