The RYR3 gene is involved in Wharton's jelly derived mesenchymal stem cell treatment of Alzheimer's disease in rats

被引：3

作者：

Ali, Hirowati ^{[1
,2
,3
,8
]}

Tofrizal, Tofrizal ^{[2
,3
,4
]}

Tjong, Djong Hon ^{[5
,6
]}

Yanis, Amel ^{[3
,7
]}

Yarni, Sisca Dwi ^{[2
,6
]}

机构：

[1] Andalas Univ, Fac Med, Dept Biochem, Padang, Indonesia

[2] Andalas Univ, Ctr Integrat Biomed Res, Biomed Lab, Padang, Indonesia

[3] Andalas Univ, Grad Sch Biomed Sci, Padang, Indonesia

[4] Andalas Univ, Fac Med, Dept Pathol Anat, Padang, Indonesia

[5] Andalas Univ, Fac Nat Sci & Math, Padang, Indonesia

[6] Andalas Univ, Grad Sch Biotechnol, Padang, Indonesia

[7] Andalas Univ, Fac Med, Dept Psychiat, Padang, Indonesia

[8] Andalas Univ, Ctr Integrat Biomed Res, Grad Sch Biomed Sci, Dept Biochem,Fac Med,Biomed Lab, Padang, Indonesia

来源：

ARCHIVES OF MEDICAL SCIENCE | 2023年 / 19卷 / 03期

关键词：

Alzheimer's disease (AD); mesenchymal stem cells (MSCs); cognitive dysfunction; RYR3; gene; Ca2+ homeostasis; RYANODINE RECEPTORS; ALUMINUM; BRAIN;

D O I：

10.5114/aoms/163353

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD). Methods: Twenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl3 group was given 300 mg/kg body weight (BW) of AlCl3 intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed. Results: MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group. Conclusions: MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.

引用

页码：820 / 824

页数：5

共 19 条

[1] Neuronal Ryanodine Receptors in Development and Aging [J].