Functional Imaging of Chemobrain: Usefulness of Nuclear Medicine in the Fog Coming After Cancer

被引：2
作者：
Chiaravalloti, Agostino [1 ,2 ]
Filippi, Luca [3 ]
Pagani, Marco [4 ,5 ]
Schillaci, Orazio [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy
[2] IRCCS Neuromed, Pozzilli, Italy
[3] Santa Maria Goretti Hosp, Nucl Med Sect, Latina, Italy
[4] CNR, Inst Cognit Sci & Technol, Rome, Italy
[5] Karolinska Hosp, Dept Med Radiat Phys & Nucl Med, Stockholm, Sweden
来源：
JOURNAL OF NUCLEAR MEDICINE | 2023年 / 64卷 / 04期
关键词：
Key Words; chemobrain; functional imaging; PET; FDG; DAT; neuroinflammation; COGNITIVE IMPAIRMENT; BREAST-CANCER; HODGKINS-LYMPHOMA; BRAIN METABOLISM; CHEMOTHERAPY; PET; HYPOMETABOLISM; NEUROTOXICITY; DYSFUNCTION; TOMOGRAPHY;
D O I：
10.2967/jnumed.121.263294
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The impact of chemotherapy on brain functionality has been widely investigated from a clinical perspective, and there is a consensus on a significant impairment of multiple cognitive domains affecting cancer patients after treatment. Nuclear medicine offers a variety of biomar-kers for evaluating possible effects of chemotherapy on the brain and for depicting brain changes after chemotherapy. This review sum-marizes the most relevant findings on brain imaging in patients undergoing chemotherapy for the most common oncologic diseases. The literature published to date offers exciting results on several radi-olabeled compounds, from the more common imaging of glucose metabolism to neuroinflammation. This review also provides a general overview of the literature concerning clinical features and the physio-pathologic basis of chemotherapy-related cognitive impairment.
引用
收藏
页码：508 / 514
页数：7
相关论文
共 61 条
[1]   Candidate mechanisms for chemotherapy-induced cognitive changes [J].
Ahles, Tim A. ;
Saykin, Andrew J. .
NATURE REVIEWS CANCER, 2007, 7 (03) :192-201
[2]   Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury [J].
Alcantara, April ;
Berenji, Gholam R. ;
Scherling, Carole S. ;
Durcanova, Beata ;
Diaz-Aguilar, Daniel ;
Silverman, Daniel H. S. .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (12) :1682-1690
[3]   Changes in Brain Structural Networks and Cognitive Functions in Testicular Cancer Patients Receiving Cisplatin-Based Chemotherapy [J].
Amidi, Ali ;
Hosseini, S. M. Hadi ;
Leemans, Alexander ;
Kesler, Shelli R. ;
Agerbaek, Mads ;
Wu, Lisa M. ;
Zachariae, Robert .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2017, 109 (12)
[4]   Lack of a chemobrain effect for adjuvant FOLFOX chemotherapy in colon cancer patients. A pilot study [J].
Andreis, Federica ;
Ferri, Marco ;
Mazzocchi, Maria ;
Meriggi, Fausto ;
Rizzi, Anna ;
Rota, Luigina ;
Di Biasi, Brunella ;
Abeni, Chiara ;
Codignola, Claudio ;
Rozzini, Renzo ;
Zaniboni, Alberto .
SUPPORTIVE CARE IN CANCER, 2013, 21 (02) :583-590
[5]   Evaluating patient-reported symptoms and late adverse effects following completion of first-line chemotherapy for ovarian cancer using the MOST (Measure of Ovarian Symptoms and Treatment concerns) [J].
Beesley, Vanessa L. ;
Ross, Tanya L. ;
King, Madeleine T. ;
Campbell, Rachel ;
Nagle, Christina M. ;
Obermair, Andreas ;
Grant, Peter ;
DeFazio, Anna ;
Webb, Penelope M. ;
Friedlander, Michael L. .
GYNECOLOGIC ONCOLOGY, 2022, 164 (02) :437-445
[6]   Chemo-brain: An activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies [J].
Bernstein, Lori J. ;
Edelstein, Kim ;
Sharma, Alisha ;
Alain, Claude .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2021, 130 :314-325
[7]   [I-123]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease [J].
Booij, J ;
Tissingh, G ;
Boer, GJ ;
Speelman, JD ;
Stoof, JC ;
Janssen, AGM ;
Wolters, EC ;
vanRoyen, EA .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (02) :133-140
[8]   Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors [J].
Carlson, Barbara W. ;
Craft, Melissa A. ;
Carlson, John R. ;
Razaq, Wajeeha ;
Deardeuff, Kelley K. ;
Benbrook, Doris M. .
GEROSCIENCE, 2018, 40 (03) :325-336
[9]   Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early-stage Colorectal Cancer [J].
Castro Sales, Manuela Vasconcelos ;
Suemoto, Claudia K. ;
Apolinario, Daniel ;
Serrao, Valeria T. ;
Andrade, Celi S. ;
Conceicao, David M. ;
Amaro Jr, Edson ;
Ribeiro de Melo, Brian Alvarez ;
Riechelmanni, Rachel P. .
CLINICAL COLORECTAL CANCER, 2019, 18 (01) :19-27
[10]   Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results [J].
Cerulla, Noemi ;
Arcusa, Angels ;
Navarro, Jose-Blas ;
de la Osa, Nuria ;
Garolera, Maite ;
Enero, Cristina ;
Chico, Gloria ;
Fernandez-Morales, Luis .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2019, 41 (03) :290-299
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