Mo(VI)-catalyzed conversion of nitriles to amides with hydrogen peroxide in ethanol

被引：6

作者：

Ma, Xiaoyun ^{[1
]}

Liu, Dan ^{[2
]}

Wan, Xiaoyan ^{[1
]}

Zhao, Jun ^{[1
]}

机构：

[1] Guizhou Educ Univ, Sch Chem & Mat Sci, Guiyang, Peoples R China

[2] Guizhou Univ, Res & Dev Ctr Fine Chem, Guiyang, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 06期

关键词：

Amide; nitrile; hydration; hydrogen peroxide; sodium molybdate; CATALYZED OXIDATION; SINGLET OXYGEN; HYDRATION; HYDROLYSIS; GENERATION; COMPLEX; FACILE; MILD;

D O I：

10.1080/00397911.2023.2178012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the preparation of primary amides from nitriles using hydrogen peroxide and a catalytic amount of sodium molybdate in ethanol is described. Using this method, nitriles including aromatic nitriles, aromatic heterocyclic nitriles and aliphatic nitriles were converted into the corresponding amides in moderate to high yields. Electronic and steric effects of substituent have a significant effect on the reactivity of nitrile, nitriles with electron-withdrawing group at the para or meta position show high reactivities and they can be converted into the corresponding amide in good to high yield at room temperature.

引用

页码：503 / 510

页数：8

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