Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes

被引：5

作者：

Okura, Tsuyoshi ^{[1
,5
]}

Nakamura, Risa ^{[1
]}

Anno, Mari ^{[1
]}

Ito, Yuichi ^{[1
]}

Kitao, Sonoko ^{[1
]}

Endo, Satomi ^{[1
]}

Taneda, Natsuka ^{[1
]}

Matsumoto, Kazuhisa ^{[1
]}

Shoji, Kyoko ^{[1
]}

Okura, Hiroko ^{[1
]}

Matsuzawa, Kazuhiko ^{[1
]}

Izawa, Shoichiro ^{[1
]}

Ueta, Etsuko ^{[2
]}

Kato, Masahiko ^{[1
]}

Imamura, Takeshi ^{[3
]}

Taniguchi, Shin-ichi ^{[4
]}

Yamamoto, Kazuhiro ^{[1
]}

机构：

[1] Tottori Univ, Div Cardiovasc Med Endocrinol & Metab, Fac Med, Yonago, Tottori, Japan

[2] Tottori Univ, Sch Hlth Sci, Fac Med, Yonago, Tottori, Japan

[3] Tottori Univ, Div Mol Pharmacol, Fac Med, Yonago, Tottori, Japan

[4] Tottori Univ, Dept Community Based Family Med, Fac Med, Yonago, Tottori, Japan

[5] Tottori Univ, Div Cardiovasc Med Endocrinol & Metab, Fac Med, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan

来源：

METABOLISM OPEN | 2023年 / 18卷

关键词：

ALDH2; polymorphism; Insulin resistance; Type; 2; diabetes; Meal tolerance test; Glucose clamp test; Obesity; GLUCOSE; SENSITIVITY; SECRETION; ALDH2;

D O I：

10.1016/j.metop.2023.100242

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme involved in alcohol metabolism. ALDH2 polymorphism has been reported as a risk factor for type 2 diabetes mellitus (T2DM) and is associated with liver insulin resistance due to alcohol consumption in non -diabetic individuals. Herein, we investigated the association between ALDH2 polymorphisms and insulin resistance in patients with T2DM. Methods: We performed a meal tolerance test and the hyperinsulinemic-euglycemic clamp on 71 Japanese participants: 34 patients with T2DM, and 37 non -diabetic participants. We analyzed the ALDH2 polymorphism (ALDH2 rs67); GG type was defined as the T2DM high -risk group, compared with the low -risk AG and AA groups. Results: Glucose levels were similar in the high- and low -risk T2DM groups. The high -risk group for T2DM showed a significantly higher BMI (p < 0.005), insulin resistance in HOMA-IR (p < 0.05), and Insulin sensitivity index (p < 0.05); however, there were no significant differences in insulin resistance in the clamp test (p = 0.10). Alcohol consumption did not differ significantly between groups (p = 0.66). Non -diabetic participants also showed higher HOMA-IR insulin resistance in the high -risk group (p < 0.05), but insulin resistance levels in the glucose clamp tests (p = 0.56) and insulin secretion were not significant. Conclusion: The results suggest that ALDH2 is an important gene associated with insulin resistance and obesity in Japanese patients with type 2 diabetes.

引用

页数：5

共 23 条

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