Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review

被引：1

作者：

Zeckanovic, Aida ^{[1
,2
]}

Fuchs, Philipp ^{[1
,2
]}

Heesen, Philip ^{[3
]}

Bodmer, Nicole ^{[1
,2
]}

Otth, Maria ^{[1
,2
,4
,5
]}

Scheinemann, Katrin ^{[4
,5
,6
,7
]}

机构：

[1] Univ Childrens Hosp Zurich, Dept Oncol, CH-8032 Zurich, Switzerland

[2] Univ Childrens Hosp Zurich, Childrens Res Ctr, CH-8032 Zurich, Switzerland

[3] Univ Zurich, Fac Med, CH-8006 Zurich, Switzerland

[4] Childrens Hosp Eastern Switzerland, Div Hematol Oncol, CH-9006 St Gallen, Switzerland

[5] Univ Lucerne, Fac Hlth Sci & Med, CH-6000 Luzern, Switzerland

[6] McMaster Childrens Hosp, Dept Pediat, Hamilton, ON L8S 4L8, Canada

[7] McMaster Univ, Hamilton, ON L8S 4L8, Canada

来源：

CURRENT ONCOLOGY | 2023年 / 30卷 / 09期

关键词：

acute lymphoblastic leukemia; adolescents and young adult; protocol; pediatric-inspired; survival; BERLIN-FRANKFURT-MUNSTER; HYPER-CVAD; CHEMOTHERAPY; PROTOCOL; TOXICITY; SURVIVAL; THERAPY;

D O I：

10.3390/curroncol30090625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 years comparing pediatric-inspired regimens (PIR) versus adult-type regimens or performing an age-stratified analysis of outcomes in the AYA population. Due to the heterogeneity of data, a meta-analysis was not possible. However, the gathered data show a trend toward improvement in outcomes and an acceptable toxicity profile in patients treated with PIRs compared to conventional adult-type regimens. There is still room for further improvement, as older patients within the AYA population tend to perform poorly with PIR or conventional adult-type chemotherapy. Further randomized studies are needed to develop an optimal treatment strategy for AYA with ALL.

引用

页码：8612 / 8632

页数：21

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