Ent-eudesmane sesquiterpenoids from the Chinese liverwort Chiloscyphus polyanthus

被引：0

作者：

Zhu, Ming-Zhu ^{[1
]}

Li, Yi ^{[1
]}

Zhou, Jin-Chuan ^{[2
]}

Lv, Dong-Xue ^{[1
]}

Fu, Xiao-Jie ^{[1
]}

Liang, Zhen ^{[1
]}

Yuan, Shuang-Zhi ^{[1
]}

Han, Jing-Jing ^{[1
]}

Zhang, Jiao-Zhen ^{[1
]}

Xu, Ze-Jun ^{[1
]}

Chang, Wen-Qiang ^{[1
]}

Lou, Hong-Xiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ,Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China

[2] Linyi Univ, Sch Pharm, Linyi 276000, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 214卷

基金：

中国国家自然科学基金;

关键词：

Liverworts; Chiloscyphus polyanthus var; rivularis; Ent-eudesmane sesquiterpenoids; Cytotoxicity; Antifungal activity; TERPENOIDS;

D O I：

10.1016/j.phytochem.2023.113796

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven previously undescribed ent-eudesmane sesquiterpenoids (1-7), as well as seven known analogs (8-14), were isolated from the Chinese liverwort Chiloscyphus polyanthus var. rivularis. Their structures were established based on comprehensive spectroscopy analysis, electronic circular dichroism calculations, as well as biosynthetic considerations. The cytotoxicity against HepG2 (Human hepatocellular carcinomas) cancer cell line, and anti fungal activity against Candida albicans SC5314 of all isolated ent-eudesmane sesquiterpenoids were preliminarily tested, results showed that the tested compounds did not display obvious cytotoxicity and antifungal activities under the tested concentration.

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页数：7

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