Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets

被引：4

作者：

Barca, Eva Gonzalez ^{[1
]}

Tomas-Roca, Laura ^{[2
]}

Esteve, Anna ^{[3
]}

Rodriguez, Marta ^{[2
,4
]}

Gato, Lucia ^{[2
]}

Alonso-Alonso, Ruth ^{[2
,4
]}

Garcia-Sancho, Alejandro Martin ^{[5
]}

Cordoba, Raul ^{[6
]}

Monter-Rovira, Anna ^{[7
]}

Bastos-Oreiro, Mariana ^{[8
]}

Burgues, Juan Miguel Bergua ^{[9
]}

Sayas, Maria Jose ^{[10
]}

Alegria, Maria Cruz Viguria ^{[11
]}

Sanchez-Blanco, Jose Javier ^{[12
]}

Pellicer, Monica Roig ^{[13
]}

Henriquez, Hugo Daniel Luzardo ^{[14
]}

de Ona, Raquel ^{[15
]}

Cabezudo, Maria Elena ^{[16
]}

Infante, Maria Stefania ^{[17
]}

Hernandez, Jose Antonio Queizan ^{[18
]}

Sanz-Pamplona, Rebeca ^{[19
,20
]}

Blanco, Oscar ^{[21
,22
]}

Mozos, Ana

Climent, Fina ^{[23
]}

Piris, Miguel Angel ^{[2
]}

机构：

[1] Univ Barcelona, Hosp Duran & Reynals, Inst Catala Oncol Hosp, Hematol Dept,IDIBELL, Barcelona, Spain

[2] Inst Invest Sanitaria Fdn Jimenez Diaz, Pathol Dept, Madrid, Spain

[3] Catalan Inst Oncol, Med Oncol Dept, Oncol Data Analyt Program ODAP, Unit Biomarkers & Susceptibil,B ARGO Badalona, Barcelona, Spain

[4] ISCIII, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[5] Hosp Clin Univ Salamanca CAUSA IBSAL, Hematol Dept, Salamanca, Spain

[6] Fdn Jimenez Diaz, Hematol Dept, Madrid, Spain

[7] Hosp Santa Creu & Sant Pau, Hematol Dept, Barcelona, Spain

[8] Gregorio Maranon Gen Univ Hosp, Hematol Dept, Madrid, Spain

[9] Hosp San Pedro Alcantara, Hematol Dept, Caceres, Spain

[10] Hosp Univ Dr Peset, Hematol Dept, Valencia, Spain

[11] Complejo Hosp Navarra, Hematol Dept, Pamplona, Spain

[12] Hosp Morales Messeguer, Hematol Dept, Murcia, Spain

[13] Hosp La Fe, Hematol Dept, Valencia, Spain

[14] Hosp Dr Negrin, Hematol Dept, Las Palmas Gran Canaria, Spain

[15] MD Anderson Canc Ctr, Hematol Dept, Madrid, Spain

[16] Hosp St Joan Despi Moises Broggi, Hematol Dept, Barcelona, Spain

[17] Hosp Infanta Leonor, Hematol Dept, Madrid, Spain

[18] Hosp Gen Segovia, Hematol Dept, Segovia, Spain

[19] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Oncol Data Analyt Program ODAP, Oncobell Program,Unit Biomarkers & Susceptibil, Barcelona, Spain

[20] CIBERESP, Barcelona, Spain

[21] Inst Biomed Res Salamanca IBSAL, Pathol Dept, Salamanca, Spain

[22] Hosp Santa Creu & Sant Pau, Pathol Dept, Barcelona, Spain

[23] Hosp Univ Bellvitge, Pathol Dept, IDIBELL, Barcelona, Spain

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2023年 / 98卷 / 06期

关键词：

PERIPHERAL T-CELL; EXPRESSION;

D O I：

10.1002/ajh.26904

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.

引用

页码：E134 / E138

页数：5

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