15 years of GWAS discovery: Realizing the promise

被引：222

作者：

Abdellaoui, Abdel ^{[1
]}

Yengo, Loic ^{[2
]}

Verweij, Karin J. H. ^{[1
]}

Visscher, Peter M. ^{[2
]}

机构：

[1] Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands

[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2023年 / 110卷 / 02期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; GENETIC RISK PREDICTION; SEVERE CROHNS-DISEASE; COMPLEX TRAITS; MENDELIAN RANDOMIZATION; MAINTENANCE THERAPY; COMMON DISEASES; BIOBANK; USTEKINUMAB; RISANKIZUMAB;

D O I：

10.1016/j.ajhg.2022.12.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It has been 15 years since the advent of the genome-wide association study (GWAS) era. Here, we review how this experimental design has realized its promise by facilitating an impressive range of discoveries with remarkable impact on multiple fields, including popula-tion genetics, complex trait genetics, epidemiology, social science, and medicine. We predict that the emergence of large-scale biobanks will continue to expand to more diverse populations and capture more of the allele frequency spectrum through whole-genome sequencing, which will further improve our ability to investigate the causes and consequences of human genetic variation for complex traits and diseases.

引用

页码：179 / 194

页数：16

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