Endotypes of atopic dermatitis and food allergy

被引：17
作者：
Hui-Beckman, Jessica W. [1 ]
Goleva, Elena [1 ]
Berdyshev, Evgeny [2 ]
Leung, Donald Y. M. [1 ,3 ]
机构：
[1] Natl Jewish Hlth, Dept Pediat, Denver, CO USA
[2] Natl Jewish Hlth, Dept Med, Denver, CO USA
[3] Natl Jewish Hlth, 1400 Jackson St,K801a, Denver, CO 80206 USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 151卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Atopic dermatitis; food allergy; filaggrin; Staphylo-coccus aureus; skin barrier; PEANUT ALLERGY; PREVENTION;
D O I：
10.1016/j.jaci.2022.07.021
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Atopic dermatitis (AD) and food allergy (FA) are strongly associated, with one-third of children with AD developing concomitant FA. Epithelial barrier dysfunction is important in both conditions. Genetic factors, such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms, are linked to increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA, as well as activating the type 2 immune response. Comprehensive multiomic studies using skin tape stripping have identified distinct atopic endotypes with unique characteristics of the stratum corneum lipids, proteins, S aureus abundance, and type 2 cytokine expression. Our new understanding of AD and FA presents an area of opportunity to move toward improved diagnosis and prevention of atopy. (J Allergy Clin Immunol 2023;151:26-8.)
引用
收藏
页码：26 / 28
页数：3
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