Real-World Treatment Patterns according to Clinical Practice Guidelines in Patients with Type 2 Diabetes Mellitus and Established Cardiovascular Disease in Korea: Multicenter, Retrospective, Observational Study

被引：4

作者：

Yang, Ye Seul ^{[1
]}

Kim, Nam Hoon ^{[2
]}

Ha Baek, Jong ^{[3
]}

Ko, Seung-Hyun ^{[4
]}

Son, Jang Won ^{[5
]}

Lee, Seung-Hwan ^{[6
]}

Rhee, Sang Youl ^{[7
]}

Kim, Soo-Kyung ^{[8
]}

Sohn, Tae Seo ^{[1
]}

Jun, Ji Eun ^{[9
]}

Jeong, In-Kyung ^{[9
]}

Kim, Chong Hwa ^{[1
,10
]}

Song, Keeho ^{[1
,11
]}

Rhee, Eun-Jung ^{[1
,2
,12
]}

Noh, Junghyun ^{[1
,3
,13
]}

Hur, Kyu Yeon ^{[14
,15
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Uijeongbu St Marys Hosp, Uijongbu, South Korea

[2] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea

[3] Gyeongsang Natl Univ, Coll Med, Gyeongsang Natl Univ Changwon Hosp, Dept Internal Med, Jinju, South Korea

[4] Catholic Univ Korea, St Vincents Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Suwon, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Bucheon St Marys Hosp, Bucheon, South Korea

[6] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Coll Med,Div Endocrinol & Metab, Seoul, South Korea

[7] Kyung Hee Univ, Kyung Hee Univ Hosp, Coll Med, Dept Endocrinol & Metab, Seoul, South Korea

[8] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Seongnam, South Korea

[9] Kyung Hee Univ Hosp Gangdong, Kyung Hee Univ, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul, South Korea

[10] Sejong Gen Hosp, Div Endocrinol & Metab, Dept Internal Med, Bucheon, South Korea

[11] Konkuk Univ, Med Ctr, Sch Med, Div Endocrinol & Metab, Seoul, South Korea

[12] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Endocrinol & Metab,Sch Med, Seoul, South Korea

[13] Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Coll Med,Div Endocrinol & Metab, Goyang, South Korea

[14] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea

[15] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, 81 Irwon Ro, Seoul 06351, South Korea

来源：

DIABETES & METABOLISM JOURNAL | 2024年 / 48卷 / 02期

关键词：

Cardiovascular diseases; Diabetes mellitus; type; 2; Guideline; Healthcare disparities; OUTCOMES;

D O I：

10.4093/dmj.2023.0225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Recent diabetes management guidelines recommend that sodium -glucose cotransporter 2 inhibitors (SGLT2is) or glucagon-like peptide 1 receptor agonists (GLP-1RAs) with proven cardiovascular benefits should be prioritized for combination therapy in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease (CVD). This study was aimed at evaluating SGLT2i or GLP-1RA usage rates and various related factors in patients with T2DM and established CVD. Methods: We enrolled adults with T2DM aged >= 30 years who were hospitalized due to established CVD from January 2019 to May 2020 at 13 secondary and tertiary hospitals in Korea in this retrospective observational study. Results: Overall, 2,050 patients were eligible for analysis among 2,107 enrolled patients. The mean patient age, diabetes duration, and glycosylated hemoglobin level were 70.0 years, 12.0 years, and 7.5%, respectively. During the mean follow-up duration of 9.7 months, 25.7% of the patients were prescribed SGLT2is after CVD events. However, only 1.8% were prescribed GLP-1RAs. Compared with SGLT2i non -users, SGLT2i users were more frequently male and obese. Furthermore, they had a shorter diabetes duration but showed worse glycemic control and better renal function at the time of the event. GLP-1RA users had a longer duration of diabetes and worse glycemic control at the time of the event than GLP-1RA non -users. Conclusion: The SGLT2i or GLP-1RA prescription rates were suboptimal in patients with T2DM and established CVD. Sex, body mass index, diabetes duration, glycemic control, and renal function were associated with the use of these agents.

引用

页码：279 / 289

页数：11

共 25 条

[21] Trends in First-Line Glucose-Lowering Drug Use in Adults With Type 2 Diabetes in Light of Emerging Evidence for SGLT-2i and GLP-1RA [J].