Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss

被引：2
|
作者：
Zhai, Tianying [1 ,2 ,3 ,4 ]
Ai, Pingping [1 ,2 ,3 ,4 ,5 ]
Tang, Zhaohui [6 ]
He, Chaoliang [6 ]
Chen, Xuesi [6 ]
Yang, Shiming [1 ,2 ,3 ,4 ]
Wu, Nan [2 ,3 ,4 ,7 ]
机构：
[1] Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
[2] Natl Clin Res Ctr Otolaryngol Dis, Beijing, Peoples R China
[3] Minist Educ, State Key Lab Hearing Sci, Beijing, Peoples R China
[4] Beijing Key Lab Hearing Impairment Prevent & Treat, Beijing, Peoples R China
[5] Zhejiang Chinese Med Univ, Hangzhou, Peoples R China
[6] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun, Peoples R China
[7] 28 Fuxing Rd, Beijing, Peoples R China
来源：
JOURNAL OF OTOLOGY | 2023年 / 18卷 / 04期
关键词：
Thermo-sensitive hydrogel; Nanodrug; Sensorineural hearing loss; Intratympanic injection; INNER-EAR DELIVERY; DRUG-DELIVERY; DEXAMETHASONE; GENTAMICIN; RELEASE; SYSTEM;
D O I：
10.1016/j.joto.2023.09.005
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness. The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity. Among them, thermo-sensitive hydrogels promote the development of new dosage form for intratympanic injection. This smart biomaterial could transform to semisolid phase when the temperature increased. Thermo-sensitive hydrogel nanodrug delivery system is expected to achieve safe, efficient, and sustained inner ear drug administration. This article introduces the key techniques and the latest progress in this field.(c) 2023 PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
引用
收藏
页码：235 / 239
页数：5
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