Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

被引：18

作者：

Jia, Dandan ^{[1
]}

Tian, Zhenjun ^{[2
]}

Wang, Ru ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Exercise & Hlth, Shanghai 200438, Peoples R China

[2] Shaanxi Normal Univ, Inst Sports & Exercise Biol, Xian 710119, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2023年 / 91卷

基金：

中国国家自然科学基金;

关键词：

Exerkines; Mitochondrial dysfunction; Ageing; Age-related diseases; NONALCOHOLIC FATTY LIVER; PHYSICAL-ACTIVITY ADVICE; OXIDATIVE STRESS; SKELETAL-MUSCLE; DIABETIC CARDIOMYOPATHY; MOLECULAR-MECHANISMS; CANCER PREVENTION; DNA MUTATIONS; MOUSE MODEL; CARDIOLIPIN;

D O I：

10.1016/j.arr.2023.102087

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The benefits of regular physical activity are related to delaying and reversing the onset of ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases, cancer, obesity, diabetes, and fatty liver diseases. However, the molecular mechanisms of the benefits of exercise or physical activity on ageing and agerelated disorders remain poorly understood. Mitochondrial dysfunction is implicated in the pathogenesis of ageing and age-related metabolic diseases. Mitochondrial health is an important mediator of cellular function. Therefore, exercise alleviates metabolic diseases in individuals with advancing ageing and age-related diseases by the remarkable promotion of mitochondrial biogenesis and function. Exerkines are identified as signaling moieties released in response to exercise. Exerkines released by exercise have potential roles in improving mitochondrial dysfunction in response to age-related disorders. This review comprehensive summarizes the benefits of exercise in metabolic diseases, linking mitochondrial dysfunction to the onset of age-related diseases. Using relevant examples utilizing this approach, the possibility of designing therapeutic interventions based on these molecular mechanisms is addressed.

引用

页数：16

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