Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

被引：18

作者：

Jia, Dandan ^{[1
]}

Tian, Zhenjun ^{[2
]}

Wang, Ru ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Exercise & Hlth, Shanghai 200438, Peoples R China

[2] Shaanxi Normal Univ, Inst Sports & Exercise Biol, Xian 710119, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2023年 / 91卷

基金：

中国国家自然科学基金;

关键词：

Exerkines; Mitochondrial dysfunction; Ageing; Age-related diseases; NONALCOHOLIC FATTY LIVER; PHYSICAL-ACTIVITY ADVICE; OXIDATIVE STRESS; SKELETAL-MUSCLE; DIABETIC CARDIOMYOPATHY; MOLECULAR-MECHANISMS; CANCER PREVENTION; DNA MUTATIONS; MOUSE MODEL; CARDIOLIPIN;

D O I：

10.1016/j.arr.2023.102087

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The benefits of regular physical activity are related to delaying and reversing the onset of ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases, cancer, obesity, diabetes, and fatty liver diseases. However, the molecular mechanisms of the benefits of exercise or physical activity on ageing and agerelated disorders remain poorly understood. Mitochondrial dysfunction is implicated in the pathogenesis of ageing and age-related metabolic diseases. Mitochondrial health is an important mediator of cellular function. Therefore, exercise alleviates metabolic diseases in individuals with advancing ageing and age-related diseases by the remarkable promotion of mitochondrial biogenesis and function. Exerkines are identified as signaling moieties released in response to exercise. Exerkines released by exercise have potential roles in improving mitochondrial dysfunction in response to age-related disorders. This review comprehensive summarizes the benefits of exercise in metabolic diseases, linking mitochondrial dysfunction to the onset of age-related diseases. Using relevant examples utilizing this approach, the possibility of designing therapeutic interventions based on these molecular mechanisms is addressed.

引用

页数：16

共 289 条

[31] Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure [J].

Carriere, Audrey ;

Jeanson, Yannick ;

Berger-Mueller, Sandra ;

Andre, Mireille ;

Chenouard, Vanessa ;

Arnaud, Emmanuelle ;

Barreau, Corinne ;

Walther, Romy ;

Galinier, Anne ;

Wdziekonski, Brigitte ;

Villageois, Phi ;

Louche, Katie ;

Collas, Philippe ;

Moro, Cedric ;

Dani, Christian ;

Villarroya, Francesc ;

Casteilla, Louis .

DIABETES, 2014, 63 (10) :3253-3265

[32] Mitochondria, Muscle Health, and Exercise with Advancing Age [J].

Carter, Heather N. ;

Chen, Chris C. W. ;

Hood, David A. .

PHYSIOLOGY, 2015, 30 (03) :208-223

[33] High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial [J].

Cassidy, Sophie ;

Thoma, Christian ;

Hallsworth, Kate ;

Parikh, Jehill ;

Hollingsworth, Kieren G. ;

Taylor, Roy ;

Jakovljevic, Djordje G. ;

Trenell, Michael I. .

DIABETOLOGIA, 2016, 59 (01) :56-66

[34] Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice [J].

Cecconi, Andrea D. Re ;

Forti, Mara ;

Chiappa, Michela ;

Zhu, Zhiyong ;

Zingman, Leonid, V ;

Cervo, Luigi ;

Beltrame, Luca ;

Marchini, Sergio ;

Piccirillo, Rosanna .

CANCERS, 2019, 11 (10)

[35] Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways [J].

Chaudhari, Snehal N. ;

Kipreos, Edward T. .

NATURE COMMUNICATIONS, 2017, 8

[36] Molecular mechanisms of exercise contributing to tissue regeneration [J].

Chen, Jibao ;

Zhou, Ren ;

Feng, Ye ;

Cheng, Lin .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)

[37] Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection [J].

Chen, Judy ;

Deng, Jane C. ;

Zemans, Rachel L. ;

Bahmed, Karim ;

Kosmider, Beata ;

Zhang, Min ;

Peters-Golden, Marc ;

Goldstein, Daniel R. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[38] MiR-30a-5p Alters Epidermal Terminal Differentiation during Aging by Regulating BNIP3L/NIX-Dependent Mitophagy [J].

Chevalier, Fabien P. ;

Rorteau, Julie ;

Ferraro, Sandra ;

Martin, Lisa S. ;

Gonzalez-Torres, Alejandro ;

Berthier, Aurore ;

El Kholti, Naima ;

Lamartine, Jerome .

CELLS, 2022, 11 (05)

[39] Exerkines in health, resilience and disease [J].

Chow, Lisa S. ;

Gerszten, Robert E. ;

Taylor, Joan M. ;

Pedersen, Bente K. ;

van Praag, Henriette ;

Trappe, Scott ;

Febbraio, Mark A. ;

Galis, Zorina S. ;

Goo, Yunling ;

Haus, Jacob M. ;

Lanza, Ian R. ;

Lavie, Carl J. ;

Lee, Chih-Hao ;

Lucia, Alejandro ;

Moro, Cedric ;

Pandey, Ambarish ;

Robbins, Jeremy M. ;

Stanford, Kristin, I ;

Thackray, Alice E. ;

Villeda, Saul ;

Watt, Matthew J. ;

Xia, Ashley ;

Zierath, Juleen R. ;

Goodpaster, Bret H. ;

Snyder, Michael P. .

NATURE REVIEWS ENDOCRINOLOGY, 2022, 18 (05) :273-289

[40] IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells [J].

Cianciulli, Antonia ;

Dragone, Teresa ;

Calvello, Rosa ;

Porro, Chiara ;

Trotta, Teresa ;

Lofrumento, Dario Domenico ;

Panaro, Maria Antonietta .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 24 (02) :369-376

← 1 2 3 4 5 6 7 8 9 10 →