Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

被引：141

作者：

Chu, Zhaoyou ^{[1
]}

Yang, Juan ^{[1
]}

Zheng, Wang ^{[1
]}

Sun, Jiangwei ^{[1
]}

Wang, Wanni ^{[1
,2
]}

Qian, Haisheng ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Anhui Prov Inst Translat Med, Sch Biomed Engn, Hefei 230032, Peoples R China

[2] Anhui Engn Res Ctr Med Micronano Devices, Hefei 230012, Anhui, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2023年 / 481卷

基金：

中国国家自然科学基金;

关键词：

Hydrogen peroxide; Tumor microenvironment; Intracellular redox state; Tumor therapy; UP-CONVERSION NANOPARTICLES; OXYGEN SPECIES GENERATION; HYDROGEN-PEROXIDE; PHOTODYNAMIC THERAPY; CATALYTIC NANOMEDICINE; CHEMODYNAMIC THERAPY; CASCADE REACTION; NITRIC-OXIDE; IN-SITU; DELIVERY;

D O I：

10.1016/j.ccr.2023.215049

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Due to the rapid proliferation of tumors, the hydrogen peroxide (H2O2) concentration of tumor cells is higher than that of normal cells, which can be used as an effective target for tumor therapy to differen-tiate normal tissues and produce differential therapeutic effects. By modulating the generation or decom-position of H2O2 in the tumor microenvironment, target molecules with more killing effects can be produced, to enhance the efficiency of tumor treatment. However, intracellular H2O2 is not sufficient to obtain satisfactory therapeutic results. In this review, we will focus on how to modulate H2O2- related strategies from two aspects, firstly by direct delivery of exogenous factors, and secondly by ampli-fying endogenous genes, which show that H2O2 regulation-based anticancer strategies are producing increasingly successful results. Finally, we discuss the obstacles that need to be solved and the bright future in the process of H2O2 modulation. (c) 2023 Elsevier B.V. All rights reserved.

引用

页数：19

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