Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential

被引：18
作者：
Gu, Jia [1 ]
Shi, Ya-Ning [1 ,2 ]
Zhu, Neng [3 ]
Li, Hong-Fang [1 ]
Zhang, Chan-Juan [1 ]
Qin, Li [1 ,4 ,5 ]
机构：
[1] Hunan Univ Chinese Med, Sch Pharm, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Sci & Technol Innovat Ctr, Changsha 410208, Hunan, Peoples R China
[3] Hunan Univ Chinese Med, Dept Urol, Hosp 1, Changsha 410021, Hunan, Peoples R China
[4] Hunan Univ Chinese Med, Hunan Prov Key Lab Vasc Biol & Translat Med, Changsha 410208, Hunan, Peoples R China
[5] Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Bioact Subst Discovery, Changsha 410208, Hunan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 164卷
关键词：
Celastrol; Lipid metabolism; Disorders; Lipid-related diseases; FATTY-ACID SYNTHASE; MITOCHONDRIAL DYSFUNCTION; INFLAMMATORY CYTOKINES; TRITERPENE CELASTROL; REVERSE CHOLESTEROL; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE STRESS; OBESITY; ATHEROSCLEROSIS;
D O I：
10.1016/j.biopha.2023.114981
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating lipid profiles and related metabolic processes, including lipid synthesis, catabolism, absorption, transport, and peroxidation. Even wild-type mice show augmented lipid metabolism after treatment with celastrol. This review aims to provide an overview of recent advancements in the lipid-regulating properties of celastrol, as well as to elucidate its underlying molecular mechanisms. Besides, potential strategies for targeted drug delivery and combination therapy are proposed to enhance the lipid-regulating effects of celastrol and avoid the limitations of its clinical application.
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页数：11
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