Fascia Layer-A Novel Target for the Application of Biomaterials in Skin Wound Healing

被引:6
作者
Ye, Haifeng [1 ]
Rinkevich, Yuval [1 ]
机构
[1] Inst Regenerat Biol & Med, Helmholtz Zentrum Munchen, Max Lebsche Pl 31, D-81377 Munich, Germany
基金
欧洲研究理事会;
关键词
fascia layer; biomaterials; new target; wound healing; MESOPOROUS BIOACTIVE GLASS; MAST-CELLS; SUBCUTANEOUS TISSUE; DERMAL FIBROBLASTS; KERATINOCYTES; ANGIOGENESIS; REGENERATION; SCAFFOLDS; MATRIX; NANOCOMPOSITES;
D O I
10.3390/ijms24032936
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual intervention for treatment. Therefore, therapeutic tools such as stem cells, biomaterials, and cytokines have been applied to the treatment of skin wounds. Skin microenvironment modulation is a key technology to promote wound repair and skin regeneration. In recent years, a series of novel bioactive materials that modulate the microenvironment and cell behavior have been developed, showing the ability to efficiently facilitate wound repair and skin attachment regeneration. Meanwhile, our lab found that the fascial layer has an indispensable role in wound healing and repair, and this review summarizes the research progress of related bioactive materials and their role in wound healing.
引用
收藏
页数:15
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