Evaluation of variable p16 immunostaining patterns, Ki-67 indices and HPV status in cervical SILs and squamous cell carcinomas: An institutional experience

被引：4

作者：

Singh, Priti ^{[1
]}

Kaushik, Sanjay ^{[1
]}

Thakur, Brijesh ^{[1
,2
]}

Acharya, Seema ^{[1
]}

Bhardwaj, Aparna ^{[1
]}

Bahal, Neelima ^{[1
]}

机构：

[1] Shri Guru Ram Rai Inst Med & Hlth Sci, Dept Pathol, Dehra Dun, Uttarakhand, India

[2] SGRRIM & HS, Dept Pathol, Dehra Dun 248001, Uttarakhand, India

来源：

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY | 2023年 / 66卷 / 01期

关键词：

Cervix; HPV; p16; ki-67; SIL; SCC; HPV-16/18 AS04-ADJUVANTED VACCINE; HUMAN-PAPILLOMAVIRUS INFECTION; OF-STUDY ANALYSIS; INTRAEPITHELIAL NEOPLASIA; CANCER; EXPRESSION; P16(INK4A); RISK; EFFICACY; PROTEIN;

D O I：

10.4103/ijpm.ijpm_656_21

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: The present study evaluates the immunoexpression of p16 and Ki-67 in cervical squamous intraepithelial lesion (SIL) and carcinomas and correlates their expression with clinicopathological features and HPV-DNA status. Material and Methods: A total 36 included cases of SIL and squamous cell carcinoma (SCC) were subjected to p16 and Ki-67 immunostaining. p16 staining was evaluated depending on grading, distribution, localization pattern, intensity and IHC score. Ki-67 expression was graded based on percentage of positive cells. Results: Incidence of HSIL and SCC cases was found to be significantly increased with parity > 5. p16 grade III diffuse nucleocytoplasmic immunostaining was observed in 62.5% LSIL, 80% HSIL and 87% SCC cases. Significant association of p16 staining intensity, IHC score and Ki-67 indices was noted with increasing grades of SILs and carcinomas. Conclusion: Our experience indicates that a combination of p16 and Ki-67 immunostaining may be useful to determine the severity of dysplastic change.

引用

页码：63 / 69

页数：7

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