Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes

被引：3
作者：
Vite, Alexia [1 ]
Matsuura, Timothy R. [1 ]
Bedi, Kenneth C. [1 ]
Flam, Emily L. [1 ]
Arany, Zoltan [1 ]
Kelly, Daniel P. [1 ]
Margulies, Kenneth B. [1 ,2 ]
机构：
[1] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Cardiovasc Inst, Perelman Sch Med, 3400 Civ Ctr Blvd,Smilow TRC 11-101, Philadelphia, PA 19104 USA
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 01期
基金：
美国国家卫生研究院;
关键词：
carbohydrates; contractility; free fatty acids; heart failure; metabolic flexibility; metabolic fuel utilization; tissue metabolites; GENE-EXPRESSION; HEART-FAILURE; KETONE-BODIES; ENERGY; EFFICIENCY;
D O I：
10.1016/j.jacbts.2023.07.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies suggest that metabolic dysregulation in patients with heart failure might contribute to myocardial contractile dysfunction. To understand the correlation between function and energy metabolism, we studied the impact of different fuel substrates on human nonfailing or failing cardiomyocytes. Consistent with the concept of metabolic flexibility, nonfailing myocytes exhibited excellent contractility in all fuels provided. However, impaired contractility was observed in failing myocytes when carbohydrates alone were used but was improved when additional substrates were added. This study demonstrates the functional significance of fuel utilization shifts in failing human cardiomyocytes.
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页码：1 / 15
页数：15
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