Promises and challenges of cardiac organoids

被引：3

作者：

Li, Jingxian ^{[1
,2
]}

Yang, Jingsi ^{[1
,2
]}

Zhao, Dandan ^{[1
,2
]}

Lei, Wei ^{[1
,2
]}

Hu, Shijun ^{[1
,2
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Dept Cardiovasc Surg, Suzhou 215000, Peoples R China

[2] Soochow Univ, Inst Cardiovasc Sci, Collaborat Innovat Ctr Hematol, Suzhou Med Coll,State Key Lab Radiat Med & Protect, Suzhou 215000, Peoples R China

来源：

MAMMALIAN GENOME | 2023年 / 34卷 / 02期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

HUMAN BRAIN-DEVELOPMENT; IN-VITRO; STEM-CELLS; MODEL; GENERATION; PRINCIPLES; REVEALS; BUILD;

D O I：

10.1007/s00335-023-09987-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases are currently the main cause of death. The study of the pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D cultured cells and animal models have certain limitations. Heart organoids as models can simulate the structure and function of the body, providing a new research strategy. This paper mainly discusses the development of organoids and their application in the study of the cardiac developmental process, drug screening and treatment of genetic and non-genetic diseases, concluding with their strengths and weaknesses.

引用

页码：351 / 356

页数：6

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