The Relationship Between Anti-Spike SARS-CoV-2 Antibody Levels and Risk of Breakthrough COVID-19 Among Fully Vaccinated Adults

被引：16

作者：

Asamoah-Boaheng, Michael ^{[1
,2
]}

Goldfarb, David M. ^{[3
]}

Karim, Mohammad Ehsanul ^{[4
,5
]}

O'Brien, Sheila F. ^{[6
,7
]}

Wall, Nechelle ^{[8
]}

Drews, Steven J. ^{[6
,9
]}

Barakauskas, Vilte ^{[3
]}

Jassem, Agatha N. ^{[3
]}

Grunau, Brian ^{[1
,4
,8
]}

机构：

[1] Univ British Columbia, Dept Emergency Med, 1190 Horby St, Vancouver, BC V6Z 2K5, Canada

[2] Mem Univ Newfoundland, Fac Med, Clin Epidemiol, St John, NL, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[4] Univ British Columbia, Ctr Hlth Evaluat & Outcome Sci, Vancouver, BC, Canada

[5] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada

[6] Canadian Blood Serv, Vancouver, BC, Canada

[7] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[8] British Columbia Emergency Hlth Serv, Vancouver, BC, Canada

[9] Univ Alberta, Div Diagnost & Appl Microbiol Lab Med & Pathol, Edmonton, AB, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 03期

关键词：

COVID-19; SARS-CoV-2; antibody levels; mRNA vaccine; Omicron;

D O I：

10.1093/infdis/jiac403

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relationship between antibodies to wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and the risk of breakthrough infections is unclear, especially during circulation of the Omicron strain. We investigated the association of anti-spike and anti-receptor binding domain antibody levels and the risk of subsequent breakthrough coronavirus disease 2019 (COVID-19). We included adult paramedics from an observational cohort study who received >= 2 mRNA vaccines but did not have COVID-19 before the blood collection. Higher postvaccination antibody levels to wild-type SARS-CoV-2 antigens were associated with a reduced risk of COVID-19. Further research into clinical utility of antibody levels, to inform a threshold for protection and timing of boosters, should be prioritized.

引用

页码：339 / 343

页数：5

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