Cell-free DNA blood test for the diagnosis of pediatric tuberculous meningitis

被引：2

作者：

Li, Guyu ^{[1
]}

Cannon, Kendall ^{[2
]}

Sisniega, Carlos ^{[3
]}

Fergie, Jaime ^{[4
]}

机构：

[1] Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Infect Dis, Rochester, MN 55905 USA

[2] Texas A&M Coll Med, Driscoll Childrens Hosp, Dept Pediat, Corpus Christi, TX 78411 USA

[3] UCLA, David Geffen Sch Med, Div Pediat Cardiol, Dept Pediat,UCLA Mattel Childrens Hosp, Los Angeles, CA 90095 USA

[4] Texas A&M Coll Med, Driscoll Childrens Hosp, Dept Crit Care Med, Corpus Christi, TX 78411 USA

来源：

JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES | 2024年 / 35卷

关键词：

Tuberculous meningitis; Children; Cell -free DNA blood test; Molecular diagnostics;

D O I：

10.1016/j.jctube.2024.100421

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pediatric tuberculous meningitis (TBM) is a severe form of tuberculosis that may present in children. The current diagnostic methods may have a limited impact on initial clinical decision-making. We present three children with tuberculous meningitis who had Mycobacterium tuberculosis complex cell-free DNA (cfDNA) detected in their blood within three days of sampling. Our cases described here illustrate for the first time the potential role of cfDNA blood tests in the rapid diagnosis of TBM.

引用

页数：3

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