Aerobic Benzylic C(sp3)-H Bond Oxygenations Catalyzed by NBS under Visible Light Irradiation

被引：8
作者：
Ye, Taiqiang [1 ]
Li, Yuzheng [1 ]
Ma, Yanni [2 ]
Tan, Shenpeng [1 ]
Li, Feng [1 ]
机构：
[1] Yantai Univ, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China
[2] Henan Acad Sci, Henan Nat Prod Biotechnol Co LTD, Zhengzhou 450002, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 89卷 / 01期
关键词：
SP(3) C-H; ALPHA-OXYGENATION; MOLECULAR-OXYGEN; OXIDATION; BENZYLPYRIDINES; ISOFLAVONOIDS; C-SP(3)-H;
D O I：
10.1021/acs.joc.3c02284
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient photocatalytic oxidation of benzylic C(sp(3))-H bonds to ketones, esters, and amides has been developed using NBS as a metal-free photocatalyst and O-2 as an oxidant. A variety of synthetically and biologically valuable compounds are assembled in moderate to excellent yields. The synthetic utility of this approach has been demonstrated by gram-scale experiments. A possible free radical mechanism was proposed to rationalize the reaction procedure.
引用
收藏
页码：534 / 540
页数：7
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