Aerobic Benzylic C(sp3)-H Bond Oxygenations Catalyzed by NBS under Visible Light Irradiation

被引：8

作者：

Ye, Taiqiang ^{[1
]}

Li, Yuzheng ^{[1
]}

Ma, Yanni ^{[2
]}

Tan, Shenpeng ^{[1
]}

Li, Feng ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China

[2] Henan Acad Sci, Henan Nat Prod Biotechnol Co LTD, Zhengzhou 450002, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 89卷 / 01期

关键词：

SP(3) C-H; ALPHA-OXYGENATION; MOLECULAR-OXYGEN; OXIDATION; BENZYLPYRIDINES; ISOFLAVONOIDS; C-SP(3)-H;

D O I：

10.1021/acs.joc.3c02284

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient photocatalytic oxidation of benzylic C(sp(3))-H bonds to ketones, esters, and amides has been developed using NBS as a metal-free photocatalyst and O-2 as an oxidant. A variety of synthetically and biologically valuable compounds are assembled in moderate to excellent yields. The synthetic utility of this approach has been demonstrated by gram-scale experiments. A possible free radical mechanism was proposed to rationalize the reaction procedure.

引用

页码：534 / 540

页数：7

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