Sesquiterpenoids from the roots of Aucklandia costus and their anti-inflammatory activities

被引：3

作者：

Lyu, Hao-Yuan ^{[1
]}

Bao, Meng-Yu ^{[1
]}

Io, Chi-Cheng ^{[1
]}

Xiong, Hao-Ming ^{[1
]}

Chen, Fei-Long ^{[1
]}

Bai, Li-Ping ^{[1
]}

Zhang, Wei ^{[1
]}

Jiang, Zhi-Hong ^{[1
]}

Zhu, Guo-Yuan ^{[1
]}

机构：

[1] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Guangdong Hong Kong Macao Joint Lab Resp Infect Di, Macau 999078, Peoples R China

来源：

FITOTERAPIA | 2023年 / 169卷

关键词：

Aucklandia costus; Sesquiterpenoid dimers; Aucklandiolides A -E; Anti-inflammatory activity; SAUSSUREA-LAPPA; LACTONES;

D O I：

10.1016/j.fitote.2023.105604

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five undescribed sesquiterpenoid dimers, aucklandiolides A-E (1-5), one new sesquiterpenoid glycoside, & beta;-cyclocostunolide-15-& beta;-D-glucopyranoside (6), and seventeen known analogues (7-23) were isolated from the roots of Aucklandia costus. Their structures were elucidated by comprehensive HRESIMS and NMR spectroscopic data analysis, and their configurations were confirmed by the computational calculations of ECD and NMR chemical shifts. Aucklandiolides A and B are the first examples of dimeric sesquiterpenoids with a unique 6/6/6/ 5/6/6 ring system originated from a proposed Diels-Alder cycloaddition between two eudesmane sesquiterpe-noids. Besides, compounds 9-11, 20, and 22 showed significant inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells at a concentration of 20 & mu;M.

引用

页数：8

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