Emerging targets for cancer treatment: S100A9/RAGE

被引：11
作者：
Valiente, M. [1 ,6 ]
Sepulveda, J. M. [2 ,3 ,7 ]
Perez, A. [2 ,3 ,4 ,5 ,7 ]
机构：
[1] CNIO, Brain Metastasis Grp, Madrid, Spain
[2] Hosp Univ 12 Octubre, Neurooncol Unit, Madrid, Spain
[3] Inst Invest Sanitaria Hosp 12 Octubre imas12, Madrid, Spain
[4] Hosp Univ 12 Octubre, Serv Neurocirugia, Madrid, Spain
[5] Univ Complutense Madrid, Fac Med, Dept Cirugia, Madrid, Spain
[6] CNIO, Brain Metastasis Grp, Madrid 28029, Spain
[7] Neurooncol Unit, Ave Cordoba,S-N, Madrid 28041, Spain
来源：
ESMO OPEN | 2023年 / 8卷 / 01期
基金：
英国科研创新办公室;
关键词：
RAGE; NF-KB; JunB; brain metastasis; radioresistance; observational prospective study; clinical trial with RAGE inhibitor; RECEPTOR; RAGE;
D O I：
10.1016/j.esmoop.2022.100751
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Developing better treatments that work for the majority of patients with brain metastasis (BM) is highly necessary. Complementarily, avoiding those therapeutic procedures that will not benefit a specific patient is also very relevant. In general, existing therapies for patients with BM could be improved in terms of molecular stratification and therapeutic efficacy. By questioning the benefit of whole brain radiotherapy as provided nowadays and the lack of biomarkers detecting radioresistance, we identified S100A9 and receptor for advanced glycation end-products (RAGE) as a liquid biopsy biomarker and a potential target for a radiosensitizer, respectively. Both of them are being clinically tested as part of the first comprehensive molecular strategy to personalized radiotherapy in BM.
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页数：5
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共 17 条
  • [1] The receptor for advanced glycation end-products supports lung tissue biomechanics
    Al-Robaiy, Samiya
    Weber, Bettina
    Simm, Andreas
    Diez, Claudius
    Rolewska, Paulina
    Silber, Rolf-Edgar
    Bartling, Babett
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2013, 305 (07) : L491 - L500
  • [2] Clinical trial design for local therapies for brain metastases: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group
    Alexander, Brian M.
    Brown, Paul D.
    Ahluwalia, Manmeet S.
    Aoyama, Hidefumi
    Baumert, Brigitta G.
    Chang, Susan M.
    Gaspar, Laurie E.
    Kalkanis, Steven N.
    Macdonald, David R.
    Mehta, Minesh P.
    Soffietti, Riccardo
    Suh, John H.
    van den Bent, Martin J.
    Vogelbaum, Michael A.
    Wefel, Jeffrey S.
    Lee, Eudocia Q.
    Wen, Patrick Y.
    [J]. LANCET ONCOLOGY, 2018, 19 (01) : E33 - E42
  • [3] Pivotal role of high-mobility group box 1 (HMGB1) signaling pathways in glioma development and progression
    Angelopoulou, Efthalia
    Piperi, Christina
    Adamopoulos, Christos
    Papavassiliou, Athanasios G.
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2016, 94 (08): : 867 - 874
  • [4] Effect of TTP488 in patients with mild to moderate Alzheimer's disease
    Burstein A.H.
    Grimes I.
    Galasko D.R.
    Aisen P.S.
    Sabbagh M.
    Mjalli A.M.M.
    [J]. BMC Neurology, 14 (1)
  • [5] Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care
    Dyhrfort, Philip
    Shen, Qiujin
    Clausen, Fredrik
    Thulin, Mans
    Enblad, Per
    Kamali-Moghaddam, Masood
    Lewen, Anders
    Hillered, Lars
    [J]. JOURNAL OF NEUROTRAUMA, 2019, 36 (20) : 2872 - 2885
  • [6] Role and Mechanisms of RAGE-Ligand Complexes and RAGE-Inhibitors in Cancer Progression
    El-Far, Ali H.
    Sroga, Grazyna
    Al Jaouni, Soad K.
    Mousa, Shaker A.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (10)
  • [7] S100B suppression alters polarization of infiltrating myeloid-derived cells in gliomas and inhibits tumor growth
    Gao, Hang
    Zhang, Ian Y.
    Zhang, Leying
    Song, Yanyan
    Liu, Shunan
    Ren, Hui
    Liu, Huili
    Zhou, Hui
    Su, Yanping
    Yang, Yihang
    Badie, Behnam
    [J]. CANCER LETTERS, 2018, 439 : 91 - 100
  • [8] Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis
    Jin, Yu
    Kang, Yalin
    Wang, Minghuan
    Wu, Bili
    Su, Beibei
    Yin, Han
    Tang, Yang
    Li, Qianxia
    Wei, Wenjie
    Mei, Qi
    Hu, Guangyuan
    Lukacs-Kornek, Veronika
    Li, Jian
    Wu, Kongming
    Yuan, Xianglin
    Wang, Wei
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)
  • [9] Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis
    Kwak, T.
    Drews-Elger, K.
    Ergonul, A.
    Miller, P. C.
    Braley, A.
    Hwang, G. H.
    Zhao, D.
    Besser, A.
    Yamamoto, Y.
    Yamamoto, H.
    El-Ashry, D.
    Slingerland, J. M.
    Lippman, M. E.
    Hudson, B. I.
    [J]. ONCOGENE, 2017, 36 (11) : 1559 - 1572
  • [10] RAGE Inhibitors as Alternatives to Dexamethasone for Managing Cerebral Edema Following Brain Tumor Surgery
    Liu, Shunan
    Song, Yanyan
    Zhang, Ian Y.
    Zhang, Leying
    Gao, Hang
    Su, Yanping
    Yang, Yihang
    Yin, Shi
    Zheng, Yawen
    Ren, Lyuzhi
    Yin, Hongwei Holly
    Pillai, Raju
    Nath, Aritro
    Medina, Eric F.
    Cosgrove, Patrick A.
    Bild, Andrea H.
    Badie, Behnam
    [J]. NEUROTHERAPEUTICS, 2022, 19 (02) : 635 - 648
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