Functional connectivity gradients of the cingulate cortex

被引:6
作者
Shen, Yuhao [1 ,2 ,3 ]
Cai, Huanhuan [1 ,2 ,3 ]
Mo, Fan [1 ,2 ,3 ]
Yao, Shanwen [1 ,2 ,3 ]
Yu, Yongqiang [1 ,2 ,3 ]
Zhu, Jiajia [1 ,2 ,3 ]
机构
[1] Hosp Anhui Med Univ, Dept Radiol, Affiliated 2, Hefei 230022, Peoples R China
[2] Res Ctr Clin Med Imaging, Hefei 230032, Anhui Province, Peoples R China
[3] Anhui Prov Inst Translat Med, Hefei 230032, Peoples R China
基金
中国国家自然科学基金;
关键词
DEFAULT-MODE NETWORK; PARCELLATION; METAANALYSIS; COGNITION;
D O I
10.1038/s42003-023-05029-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Heterogeneity of the cingulate cortex is evident in multiple dimensions including anatomy, function, connectivity, and involvement in networks and diseases. Using the recently developed functional connectivity gradient approach and resting-state functional MRI data, we found three functional connectivity gradients that captured distinct dimensions of cingulate hierarchical organization. The principal gradient exhibited a radiating organization with transitions from the middle toward both anterior and posterior parts of the cingulate cortex and was related to canonical functional networks and corresponding behavioral domains. The second gradient showed an anterior-posterior axis across the cingulate cortex and had prominent geometric distance dependence. The third gradient displayed a marked differentiation of subgenual and caudal middle with other parts of the cingulate cortex and was associated with cortical morphology. Aside from providing an updated framework for understanding the multifaceted nature of cingulate heterogeneity, the observed hierarchical organization of the cingulate cortex may constitute a novel research agenda with potential applications in basic and clinical neuroscience. Analysis of resting-state fMRI data reveals the presence of functional connectivity gradients of the human cingulate cortex, which updates our understanding of cingulate heterogeneity.
引用
收藏
页数:9
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