Synthesis and Anticancer Evaluation of Novel 7-Aza-Coumarine-3-Carboxamides

被引：5

作者：

Trifonov, Alexey V. ^{[1
]}

Gazizov, Almir S. ^{[1
]}

Tapalova, Anipa S. ^{[2
]}

Kibardina, Lyudmila K. ^{[1
]}

Appazov, Nurbol O. ^{[2
]}

Voloshina, Alexandra D. ^{[1
]}

Sapunova, Anastasiia S. ^{[1
]}

Luybina, Anna P. ^{[1
]}

Abyzbekova, Gulmira M. ^{[2
]}

Dobrynin, Alexey B. ^{[1
]}

Litvinov, Igor A. ^{[1
]}

Tauekel, Akerke K. ^{[3
]}

Yespenbetova, Sholpan O. ^{[2
]}

Burilov, Alexander R. ^{[1
]}

Pudovik, Michail A. ^{[1
]}

机构：

[1] Russian Acad Sci, Arbuzov Inst Organ & Phys Chem, FRC Kazan Sci Ctr, Arbuzova Str 8, Kazan 420088, Russia

[2] Korkyt Ata Kyzylorda Univ, Aiteke Bi St 29A, Kyzylorda 120014, Kazakhstan

[3] Kazan Natl Res Technol Univ, Dept Oil Chem & Nanotechnol, Karl Marx Str 68, Kazan 420015, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

aza-coumarine; amides; cytotoxicity; selectivity; anti-tumor; OPTICAL-PROPERTIES; SCAFFOLD; DERIVATIVES; COUMARINS; AGENTS;

D O I：

10.3390/ijms24129927

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, we report the design and synthesis of novel 7-aza-coumarine-3-carboxamides via scaffold-hopping strategy and evaluation of their in vitro anticancer activity. Additionally, the improved non-catalytic synthesis of 7-azacoumarin-3-carboxylic acid is reported, which features water as the reaction medium and provides a convenient alternative to the known methods. The anticancer activity of the most potent 7-aza-coumarine-3-carboxamides against the HuTu 80 cell line is equal to that of reference Doxorubicin, while the selectivity towards the normal cell line is 9-14 fold higher.

引用

页数：19

共 50 条

[41] Synthesis, characterization and evaluation of novel isoquinoline analogues as anticancer agents
Ambati, Anna Reddy
Gangula, Mohan Rao
Murahari, Kiran Kumar
Uppula, Purushotham
Tanneeru, Karunakar
Baru, Vijaya kumar
JOURNAL OF MOLECULAR STRUCTURE, 2025, 1321
[42] Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents
Wan, Maosheng
Xu, Linyan
Hua, Li
Li, Ailing
Li, Shuqing
Lu, Wenjing
Pang, Yue
Cao, Chengbo
Liu, Xiangguo
Jiao, Peifu
BIOORGANIC CHEMISTRY, 2014, 54 : 38 - 43
[43] Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity
Balbi, Alessandro
Anzaldi, Maria
Maccio, Chiara
Aiello, Cinzia
Mazzei, Mauro
Gangemi, Rosaria
Castagnola, Patrizio
Miele, Mariangela
Rosano, Camillo
Viale, Maurizio
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) : 5293 - 5309
[44] Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues
Moghadam, Ebrahim S.
Saravani, Farhad
Ostad, Seyednasser
Tavajohi, Shohreh
Hamedani, Mortcla P.
Amini, Mohsen
MEDICINAL CHEMISTRY, 2019, 15 (03) : 231 - 239
[45] Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives
Xiao Ming Zha~(a
ChineseChemicalLetters, 2010, 21 (09) : 1087 - 1090
[46] Synthesis, antimicrobial, and anticancer evaluation of novel 2-(3-methylindolyl)benzimidazole derivatives
P. N. Kishore Babu
B. Ramadevi
Y. Poornachandra
C. Ganesh Kumar
Medicinal Chemistry Research, 2014, 23 : 3970 - 3978
[47] Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones
Machakanur, Shrinath S.
Patil, Basavaraj R.
Badiger, Dayananda S.
Bakale, Raghavendra P.
Gudasi, Kalagouda B.
Bligh, S. W. Annie
JOURNAL OF MOLECULAR STRUCTURE, 2012, 1011 : 121 - 127
[48] Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents
Chen, Yi-Fong
Lin, Yi-Chien
Chen, Jeng-Pang
Chan, Hsu-Chin
Hsu, Mei-Hua
Lin, Hui-Yi
Kuo, Sheng-Chu
Huang, Li-Jiau
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (18) : 3873 - 3877
[49] Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers
Thi Nhung Dao
Hong Hieu Truong
Van Boi Luu
Soldatenkov, Anatoly T.
Kolyadina, Nadezhda M.
Kulakova, Alena N.
Khrustalev, Victor N.
Wodajo, Ayalew T.
Hong Quan Nguyen
Thi Tan Van Tran
Tuan Anh Le
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (07) : 654 - 659
[50] Design, synthesis, in silico and biological evaluation of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazine carboxamides
Kumari, Shikha
Mishra, Chandra Bhushan
Idrees, Danish
Prakash, Amresh
Yadav, Rajesh
Hassan, Md. Imtaiyaz
Tiwari, Manisha
MOLECULAR DIVERSITY, 2017, 21 (01) : 163 - 174

← 1 2 3 4 5 →